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Head and neck cancers can be treated with curative intent in the early stages by surgery or radiotherapy. Locally advanced carcinomas may not be controlled by single modality therapy, and local progression is the predominant cause of death. Radio-chemotherapy is gaining importance as primary treatment (Al-Sarraf 1988). Mitomycin-C, 5-fluorouracil (5-FU), bleomycin, methotrexate, and platinum derivatives have been used simultaneously with radiotherapy and have proven to be effective (Bachaud et al. 1991; Fu et al. 1987; Marcial et al. 1988; Sanchiz et al. 1990; Schnabel et al. 1991, 1992; Weissenberg et al. 1989; Wendt et al. 1988; Zamboglou et al. 1992). Unfortunately, some of these agents enhance mucosal reactions of concomitant radiotherapy (Fu et al. 1987; Wendt et al. 1988). In contrast, platinum derivatives do not enhance mucositis (Zambouglou et al. 1989, 1992). We report here on our experience using conventional and hyperfractionated, accelerated radiotherapy in combination with cisplatin and carboplatin in the management of advanced head and neck carcinomas as well as radiobiological investigations.