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If you are contemplating setting up a business in China, you will need to consider what structure to use. But before deciding on the structure, you need to be sure of your strategy—strategy must lead structure. You must first consider why you want to make an investment in China, and find out just what you should be doing, before determining exactly how to do it.

Magnetic Resonance Imaging (MRI) induced heating on patients with pacemaker (PM) or implantable cardioverter-defibrillator (ICD) can pose severe health risks. Experimental studies in this field have shown a great variability in results and revealed that several aspects can affect the amount of heating induced at the lead tip. The structural parameters of the lead are one of these. In this study we performed in-vitro temperature measurements of PM/ICD leads inside a human trunk simulator exposed to the RF field of a 1.5T MRI scanner. A total of 26 leads were tested (23 PM leads, 3 ICD leads) and the temperature increases induced by the RF field ranged from 2.1°C to 15.0°C. Significant heating was observed not only at the lead tip, but also at the ring (as high as 4.2°C), even if not in all the bipolar leads tested. Active-fix leads showed higher temperature increases than passive-fix ones (4.7°C versus 7.4°C).

The development of a new drug is an enormously largescale and expensive process. Thus, computer simulation methods become to play an increasing role in the development of new pharmacologically active compounds. Most of the commercial software presently used, comes from the U.S.; their deficits have become more and more obvious during the last years. Several methods have been developed in our project to alleviate these problems. The search for new lead structures starts with analyzing large databases of compounds (several hundreds of thousands up to several millions of compounds) zeroing into a few promising structures by increasing sophistication of structure representation. Due to the large number of chemical compounds, a systematic scheme for representing structures was developed: The starting point is the constitution, followed by calculation of the 3D structure, then including conformational flexibility. At each step, a variety of chemical properties can be taken into consideration. In addition, new programs have been developed for the treatment of conformational flexibility. The methods presented are also useful for other areas of application dealing with chemical information. Thus, it was shown that one of these new structure representations is suitable for treating problems in combinatorial synthesis. Neural networks and genetic algorithms are highly important for the investigation of the correlation between structure and biological activity. Complex relationships and huge amounts of data can be processed by these methods. Implementation of these procedures on highly parallel computers has proved that datasets of several hundreds of thousands of structures can be treated with acceptable computation times.