Localized fat deposit in man and woman represents one of the main causes of dissatisfaction of the body image in this millennium, where the consideration for a slim and pleasant proportioned body has taken the place of the fat woman of the middle ages at the beginning of 1900. New models introduced by the media and imaging have pushed the population to follow diet and regime to try to be on shape, and for most of the lifetime, struggling against the temptations of good food and lazy life. Healthy food, gymnastics, exercise, and running are all types of new trends of life scenario that have been introduced in the last 20 years and have revolutionized our lifestyle. Despite all these attempts, fat deposits in women and men have remained unchanged. This is mainly because of hereditary disturbance of constitution and hormonal change mostly in woman, rather than for the difficulty of most races, such as Black and Arab, to change their style of life and nutrition through the ages. The new generation is very focused on the aspects of the body, aiming to be slim and sexy and devote great attention to nutrition, exercise, and body enhancement. For limited areas of fat accumulation, what we generally call lipodystrophies, a new treatment has been introduced recently following the previous experience of internal and external ultrasound energy.