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Your search keyword '"Stereotactic biopsy"' showing total 93 results
Start Over Descriptor "Stereotactic biopsy" Publisher springer berlin heidelberg
93 results on '"Stereotactic biopsy"'

4. Meta-analysis of overall survival and postoperative neurologic deficits after resection or biopsy of butterfly glioblastoma

Author

Soliman, Mohamed AR, Khan, Asham, Azmy, Shady, Gilbert, Olivia, Khan, Slah, Goliber, Ryan, Szczecinski, Eric J, Durrani, Hamza, Burke, Samantha, Salem, Amany A, Lubanska, Dorota, Ghannam, Moleca M, Hess, Ryan M, Lim, Jaims, Mullin, Jeffrey P, Davies, Jason M, Pollina, John, Snyder, Kenneth V, Siddiqui, Adnan H, Levy, Elad I, Plunkett, Robert J, and Fenstermaker, Robert A

Published
2022
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9. Thalamic Gliomas

Author

Sainte-Rose, Christian, Crimmins, Darach W., Grill, Jacques, Tonn, Jörg-Christian, editor, Westphal, Manfred, editor, and Rutka, James T., editor

Published
2010
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10. Midbrain Gliomas

Author

Albright, A. Leland, Rocque, Brandon G., Tonn, Jörg-Christian, editor, Westphal, Manfred, editor, and Rutka, James T., editor

Published
2010
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30. Brain Tumors

Author

Wong, T. Z., Coleman, R. E., Bender, Hans, editor, Palmedo, Holger, editor, Biersack, Hans-Jürgen, editor, and Valk, Peter E., editor

Published
2000
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48. Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

Author

Nathalene Truffaux, David Castel, Patrick Saulnier, Raphael Calmon, Ludivine Le Dret, Felipe Andreiuolo, Thomas Blauwblomme, Pascale Varlet, Marie-Anne Debily, Alan Mackay, Ludovic Lacroix, Stéphanie Puget, Christian Sainte-Rose, Kathryn R. Taylor, Mélanie Pagès, Jacques Grill, Nathalie Boddaert, Chris Jones, and Cathy Philippe

Subjects
Male, Pathology, medicine.medical_specialty, Stereotactic biopsy, PDGFRA, Biology, Pathology and Forensic Medicine, Cohort Studies, Histones, Cellular and Molecular Neuroscience, Histone H3, Glioma, Pons, Correspondence, medicine, Brain Stem Neoplasms, Humans, Child, Neurons, H3 K27M Mutation, Original Paper, medicine.diagnostic_test, medicine.disease, Prognosis, Phenotype, Gene expression profiling, Oligodendroglia, Histone, Astrocytes, Child, Preschool, Mutation, Cancer research, biology.protein, Female, Neurology (clinical), HeLa Cells
Abstract

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one biological entity. The aim of the study was to determine the clinical and biological variables that most impact their prognosis. Ninety-one patients with classically defined DIPG underwent a systematic stereotactic biopsy and were included in this observational retrospective study. Histone H3 genes mutations were assessed by immunochemistry and direct sequencing, whilst global gene expression profiling and chromosomal imbalances were determined by microarrays. A full description of the MRI findings at diagnosis and at relapse was integrated with the molecular profiling data and clinical outcome. All DIPG but one were found to harbour either a somatic H3-K27M mutation and/or loss of H3K27 trimethylation. We also discovered a novel K27M mutation in HIST2H3C, and a lysine-to-isoleucine substitution (K27I) in H3F3A, also creating a loss of trimethylation. Patients with tumours harbouring a K27M mutation in H3.3 (H3F3A) did not respond clinically to radiotherapy as well, relapsed significantly earlier and exhibited more metastatic recurrences than those in H3.1 (HIST1H3B/C). H3.3-K27M-mutated DIPG have a proneural/oligodendroglial phenotype and a pro-metastatic gene expression signature with PDGFRA activation, while H3.1-K27M-mutated tumours exhibit a mesenchymal/astrocytic phenotype and a pro-angiogenic/hypoxic signature supported by expression profiling and radiological findings. H3K27 alterations appear as the founding event in DIPG and the mutations in the two main histone H3 variants drive two distinct oncogenic programmes with potential specific therapeutic targets. Electronic supplementary material The online version of this article (doi:10.1007/s00401-015-1478-0) contains supplementary material, which is available to authorized users.

Published
2015

50. The safety and effectiveness of low field intraoperative MRI guidance in frameless stereotactic biopsies of brain tumours—design and interim analysis of a prospective randomized trial

Author

L. W. Zub, Marcin Czyz, Paweł Tabakow, B. E. Lechowicz-Głogowska, Artur Weiser, and Włodzimierz Jarmundowicz

Subjects
Adult, Male, medicine.medical_specialty, Stereotactic biopsy, Interventional magnetic resonance imaging, Biopsy, Clinical Neurology, Neurosurgical Procedures, Intraoperative MRI, law.invention, Stereotaxic Techniques, Intraoperative Period, Young Adult, Postoperative Complications, Randomized controlled trial, law, Frameless stereotaxy, medicine, Humans, Prospective Studies, Aged, Aged, 80 and over, Postoperative Care, medicine.diagnostic_test, business.industry, Brain Neoplasms, Image-guided neurosurgery, Postoperative complication, Brain tumour, General Medicine, Length of Stay, Middle Aged, Interim analysis, Magnetic Resonance Imaging, Surgery, Treatment Outcome, Surgery, Computer-Assisted, Needles, Stereotaxic technique, Original Article, Female, Neurology (clinical), Radiology, Intraoperative magnetic resonance, business
Abstract

The aim of the study was to assess the safety and effectiveness of stereotactic brain tumour biopsy (STx biopsy) guided by low-field intraoperative magnetic resonance imaging (iMRI) in comparison with its frameless classic analogue based on a prospective randomized trial. A pilot group of 42 brain tumour patients was prospectively randomized into a low-field iMRI group and a control group that underwent a frameless STx biopsy. The primary endpoints of the analysis were postoperative complication rate and diagnostic yield, and the secondary endpoints were length of hospital stay and duration of operation. The iMRI group (21 patients) and the control group (21 patients) did not differ significantly according to demographic and epidemiological data. No major postoperative complications were noted in either group. In addition, no significant differences in the diagnostic yield (p = 1.00) and length of hospital stay (p = 0.16) were observed. The mean total OR time was 111 ± 24 min in iMRI and 78 ± 29 min in the control group (p = 0.0001). Usage of iMRI may prolong the time of the procedure but seems to be comparable in safety and effectiveness to the standard frameless STx biopsy.

Published
2013

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