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During the past 15 years, several methods of endoscopic hemostasis have been evaluated in clinical studies, for injection therapy with adrenalin/polidocanol. However, these substances may produce tissue damage. In some pilot studies, excellent results concerning initial and definitive control of peptic ulcer hemorrhage were obtained with submucosal injection of a fibrin tissue adhesive.

Gastro-oesophageal reflux is a very distressing problem for many patients [1]. Normally it responds well to medical treatment. However, in some patients surgical intervention is required [2]. The Belsey Mark IV, the Hill and the Nissen fun-doplication are the commonly employed operations. The Angelchik prosthesis is the most recent innovation as an anti-reflux procedure [3]. One of the main objectives of surgery is to increase the lower oesophageal sphincter pressure (LOSP). Hill has suggested that an increase in intraoperative LOSP is mandatory for a successful anti-reflux operation [4].