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Acute Kidney Injury (AKI) associated with Scrub typhus is an emerging health problem which is more common in the tropics including India. This study intended to find out the occurrence of Scrub typhus among the Community Acquired Acute Kidney Injury patients in a tertiary care hospital in Assam, North East India. AKI patients with acute febrile illness admitted to Gauhati Medical College and Hospital, Guwahati, Assam were included in the study and demographic characteristics along with clinical features were recorded. The detection of Scrub typhus was done by IgM Enzyme Linked Immunosorbent Assay (ELISA) test (Optical Density > 0.5) and polymerase chain reaction (PCR) analysis. Routine haematological and biochemical tests were performed. Molecular characterization of Orientia tsutsugamushi was done followed by phylogenetic analysis. The Graph Pad Prism software 9 was used for statistical analysis. Out of 221 AKI patients admitted to hospital, 45 patients (20.4%) were confirmed to be Scrub typhus positive and among them, 4 cases were co-infected with leptospirosis. Majority of Scrub typhus positive AKI patients were in Stage I (82.2%) under KDIGO guideline. "Karp" was the predominant circulating serotype. The study showed cases of Scrub typhus associated Acute Kidney Injury was high and mortality was 11.1%. Hence, in this region, further studies need to be done with large number of population and more emphasis need to be given on differential diagnosis., Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-023-01137-x., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© Association of Microbiologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

An 8 years old male Burmese Red Serow ( Capricornis sumatraensis sub species rubidus ) from Aizawl Zoological Park was presented to the Teaching Veterinary Clinical Complex. An exploratory skin scraping revealed existence of nymphal as well as adult stages of mites of the Psoroptes spp. which were not associated with any overt lesions typical to mite infestation such as pruritus, erythema or scaling of the epidermis. The mites were identified as per their morphology, size and shape. Haemato-biochemical analysis revealed alteration of certain haematological and biochemical parameters. The red blood corpuscles were found to have anucleate cells with mild to absent central pallor. The absolute counts showed neutrophilic leucocytosis with mild monocytosis and lymphocytosis. Eosinophilic count was towards the higher side, indicating that the infestation was mild. The serum calcium, albumin, triglyceride, urea nitrogen (BUN) were found to be lower than normal, whereas serum ALT, AST, LDH, ALP and serum amylase were higher than the established reference indices. Due to lack of haemato-biochemical reference values specific to captive Serow, emphasis was given in this report to establish baseline data for this species., Competing Interests: Compliance with ethical standardsThe authors declare that there is no conflict of interest.

The present report communicates a case of canine trypanosomosis with ophthalmic involvement, its diagnosis, hemato-biochemistry and therapeutic management in a 2 year old dog. The dog had history of bilateral corneal opacity and impaired vision since last 4 weeks. On the basis of history and clinical signs, a presumptive diagnosis of canine trypanosomosis was made followed by confirmation with Giemsa stained buffy coat smear examination. Therapeutic regimen was comprised of Diminazine aceturate @ 3.5 mg/kg deep IM for two occasions 24 h apart along with parenteral fluids, hematinics, NSAID and multivitamins which yielded favourable response by third day post-therapy. Haemato-biochemical parameters took nearly 14 days of time to return to near normal levels. Improvement with respect to corneal opacity took 6 weeks of time and the animal was followed up to 3 months without any recurrence.

To know the prevalence of theileriosis infection, haemato-biochemical alteration and efficacy of Oxytetracycline in combination with Diaminazene aceturate injection against theileriosis in Lushai hill district of Mizoram; fifty five cross bred cattle were screened during July, 2013 to November, 2013. The prevalence of tropical theileriosis was 9.09 % based on blood smear examination. Clinical features of the disease were manifested by high rise of body temperature 104.8 ± 1.2 °F, lymphadenopathy, inability to walk, anorexia, listlessness, moderate anaemia, nasal discharge, edema of eye and corneal opacity. There were marked decline (P < 0.01) in the haemoglobin 5.28 ± 1.81 gm/dl, total erythrocytic count 2.14 ± 0.7 × 10(6)/ul, packed cell volume 18.10 ± 0.8 % and total leukocyte count 6.95 ± 1.05 × 10(3)/ul, respectively. Erythrocyte sedimentation rate was significantly increased (P < 0.01) up to 104.5 ± 12.4 mm/1st hour. The percentage of neutrophils increased 62.75 ± 2.77 and lymphocytes decreased drastically 28.69 ± 1.45 as compared with un-infected cross bred cattle. Clinically infected cattle with Theileria annulata had significantly low levels of total proteins and albumin, (P < 0.05) but AST, total, direct and indirect bilirubin, BUN, creatinine levels and Ck-MB activity were significantly high (P < 0.05). Oxytetracycline in combination with Diaminazene aceturate was found effective against T. annulata and could control fever and temperature returns to normalcy by 7th day post treatment along with some haemato-biochemical profiles. In brief, the study revealed that tropical theileriosis was prevalent in Lushai hill district of Mizoram especially among cross breed cattle and had effect on hepatic, renal and cardiac function which can be effectively controlled by Oxytetracycline and Diaminazene aceturate injection.

Tick-borne infectious diseases constitute an emerging problem in Veterinary Medicine. The study was undertaken to find out the ultrasonographic changes of liver and spleen in 101 positive cases of tick borne intracellular haemoparasitic diseases in dogs. Abdominal survey of ultrasonography revealed hypo echogenicity of liver, gall bladder distension, splenomegaly, hepato-splenomegaly and ascites in various tick born intracellular diseases viz. ehrlichiosis, babesiosis, anaplasmosis, hepatozoonosis and in mixed infection. Correlating these USG finding with other laboratory examination will be very much useful to spot the diseases condition and organ involvement in tick born intracellular diseases of dog.