1. X-chromosome inactivation and escape.
- Author
-
Disteche CM and Berletch JB
- Subjects
- Animals, Humans, Gene Silencing physiology, X Chromosome genetics, X Chromosome Inactivation genetics
- Abstract
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.
- Published
- 2015
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