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Biochemistry in our University originated in the Faculty of Medicine thanks to two doctors, Prof. Giorgio Lenaz and Prof. Giovanna Curatola, hence the interest in the study of molecular modifications at the basis of different pathologies. Writing an article that celebrates the long journey of Biochemistry in our University has not been easy, but I think the mark that nitric oxide (NO) has left in the scientific-academic path of biochemical-medical research born in our Polytechnic is fundamental. Nitric oxide is a molecule of fundamental importance for the physiology of the organism and is able to carry out its biological actions both in the intracellular and extracellular compartments. This molecule, involved in the regulation of numerous metabolic pathways, seems to play an important role also in the mechanisms underlying the pathologies we are interested in our research: DIABETES, NEONATAL MEDICINE, PREGNANCY, FERTILITY AND AGING AND RELATED PATHOLOGIES. In this memorandum we have omitted for the sake of brevity other very important studies on psycho-dysmetabolic pathologies such as anorexia nervosa where we highlighted the importance of dietary supplementation of L-Arginine and also the formulation of an enriched extra virgin olive oil with both of the abovementioned amino acid and others, complementary to its metabolism, formulation patented by us. The research stories do not have, and we researchers do not want them to have, conclusions because this would put limits on the development of research itself which we hope will continue with as much and perhaps better progress for the health of men and, why not, of women.