1. Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
- Author
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Prashant Kesharwani, Harish Rajak, Bapi Gorain, Vijay K. Patel, Talha Jawaid, Mehnaz Kamal, Ekta Shirbhate, and Jaiprakash Pandey
- Subjects
Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Acute Lung Injury ,Disease ,Review ,Bioinformatics ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Intervention (counseling) ,Medicine ,Humans ,rhACE2 ,Receptor ,Pharmacology ,Acute respiratory distress syndrome ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,COVID-19 Drug Treatment ,030220 oncology & carcinogenesis ,Angiotensin-converting enzyme 2 ,Hypertension ,Spike Glycoprotein, Coronavirus ,Angiotensin-converting enzyme-2 ,Cell response ,Angiotensin-Converting Enzyme 2 ,business ,030217 neurology & neurosurgery ,hormones, hormone substitutes, and hormone antagonists - Abstract
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
- Published
- 2021