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Cardiogenic shock is a complex clinical status characterized by a progressive multi-organ dysfunction determined by the failure of the heart to deliver an adequate amount of blood to the tissues. It complicates approximately 5–10% of cases with acute myocardial infarction. Ischemia due to decreased coronary perfusion leads to muscle hypoxia and necrosis which compromises myocardial contractility. This leads to decreased cardiac output and a subsequent drop in the arterial blood pressure. Coronary revascularization should be performed as soon as possible after AMI and shock onset. After the SHOCK trial, we have witnessed the reduction in the incidence of cardiogenic shock due to early revascularization. Although the primary endpoint, all-cause mortality at 30 days, did not differ between the initial medical stabilization and early revascularization group, there was a significant decrease in mortality after 1 and 6 years in patients assigned to early revascularization. In this chapter incidence, pathophysiology, etiology, clinical symptoms, and therapeutic options in cardiogenic shock are discussed. Two clinical cases and a case scenario allow the reader to get through the content.