1. Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia
- Author
-
Amedeo Zurlo, Carlo Cervellati, Alessandro Trentini, Cristina Bosi, Angelina Passaro, Giuseppe Valacchi, Mario Luca Morieri, Giovanni Zuliani, and Gloria Brombo
- Subjects
0301 basic medicine ,Male ,030213 general clinical medicine ,Aging ,Activities of daily living ,Disease ,Alzheimer’s disease ,Dementia ,Functional abilities ,Inflammation ,Mixed dementia ,Activities of Daily Living ,Aged ,Aged, 80 and over ,Alzheimer Disease ,Analysis of Variance ,C-Reactive Protein ,Case-Control Studies ,Cognitive Dysfunction ,Disability Evaluation ,Disease Progression ,Female ,Geriatric Assessment ,Homocysteine ,Humans ,Italy ,Reference Values ,Retrospective Studies ,Systemic inflammation ,0302 clinical medicine ,Economica ,80 and over ,Geriatrics and Gerontology ,Confounding ,Original Article ,medicine.symptom ,medicine.medical_specialty ,03 medical and health sciences ,Internal medicine ,mental disorders ,medicine ,030109 nutrition & dietetics ,business.industry ,Odds ratio ,medicine.disease ,Comorbidity ,Confidence interval ,business ,human activities - Abstract
The decline in basic and instrumental activities of daily living (BADLs and IADLs, respectively) is a well-established clinical hallmark of dementia. Growing evidence has shown that systemic subclinical inflammation may be related to functional impairment. We evaluated the possible association between low-grade systemic inflammation and functional disability in older individuals affected by dementia. We explored the association between high-sensitivity C-reactive protein (hs-CRP) levels and BADLs/IADLs in older individuals affected by late onset Alzheimer's disease (LOAD; n 110), "mixed" dementia (n 135), or mild cognitive impairment (MCI; n 258), and compared them with 75 normal Controls. Independent of age, gender, comorbidity, and other potential confounders, higher hs-CRP was significantly associated with poorer BADLs (loss ≥ 1 function) in people with LOAD (odds ratio [OR] 3.14, 95% confidence interval [CI], 1.33-7.33) and mixed dementia (OR 2.48, 95%CI 1.12-5.55), but not in those with MCI (OR 1.38, 95%CI 0.83-2.45) or Controls (OR 2.98, 95%CI 0.54-10.10). No association emerged between hs-CRP and IADLs in any of the sub-group. Our data suggest that systemic low-grade inflammation may contribute to functional disability in older patients with dementia.
- Published
- 2018