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The advent of minimally invasive surgery was characterized by a massive switch of the majority of surgeons from open cholecystectomy to the laparoscopic technique, often pushed by the patients, who required this less invasive approach. Single-port access was introduced during the phase of exploring natural orifice surgery. The obvious advantage was the reduction of access trocars; however, the procedure through the limited “single” port was quite cumbersome because of the nature of the technique. The popularity of single-port surgery and cholecystectomy decreased in the past 5–10 years again. A new platform for this technique is the Fortimedix Surgical SymphonX™ system with a diameter of only 15 mm. This system allows for the introduction of a camera and of two non-crossing, articulating instruments, which create a comfortable working platform with space to manipulate instruments and tissue, incorporating features comparable to robotic surgery. SymphonX™ carries the ability to perform a laparoscopic procedure such as a cholecystectomy without an additional trocar. Clinical studies show promising results.