1. Diagnostic values of delayed additional FDG PET/CT scan in the evaluation of cardiac sarcoidosis.
- Author
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Manabe O, Takahashi K, Kawakami H, Ohtsuka A, Aikawa T, Maki H, Ibe T, Fujita H, and Oyama-Manabe N
- Subjects
- Humans, Female, Aged, Fluorodeoxyglucose F18, Radiopharmaceuticals, Retrospective Studies, Positron-Emission Tomography methods, Tomography, X-Ray Computed methods, Positron Emission Tomography Computed Tomography methods, Sarcoidosis diagnostic imaging
- Abstract
Objective: This study aimed to compare the contribution of
18 F-fluorodepxyglucose (FDG) positron (PET)/ computed tomography (CT) acquisition of early and delayed scans in patients with cardiac sarcoidosis (CS)., Methods: Twenty-three patients with CS (median age: 69 years; 11 women) were retrospectively evaluated using dual-phase FDG PET/CT. All patients were instructed to consume a low-carbohydrate diet followed by fasting for 18 h before FDG injection to reduce physiological myocardial uptake. PET/CT was acquired at 60 min (early) and 100 min (delayed) after FDG administration. Focal and focal on diffuse uptake on visual analysis was considered positive for CS. A semi-quantitative analysis was performed using the maximum standardized uptake value (SUVmax) of the cardiac lesion and the mean SUV (SUVmean) of the blood pool., Results: Significant myocardial FDG uptake was observed in 21 patients (91.3%) in the early acquisition group and in 23 patients in the delayed scan group (100%). Compared to the early scan, the delayed scan showed a significantly higher SUVmax of the cardiac lesion [median, 4.0; IQR (interquartile range, 2.9 to 7.0) vs. 5.8 (IQR 3.7 to 10.1); P = 0.0030] and a significantly lower SUVmean of blood pool [median, 1.3 (IQR, 1.2 to 1.4) vs. 1.1 (IQR, 0.9 to 1.2); P < 0.0001]., Conclusion: Delayed FDG PET/CT acquisition improves detection accuracy in patients with CS compared to early scans with washout of the blood pool activity. Therefore, it can contribute to a more accurate assessment of CS., (© 2023. The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.)- Published
- 2023
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