1. Replicating genotype–phenotype associations.
- Author
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Chanock, Stephen J., Manolio, Teri, Boehnke, Michael, Boerwinkle, Eric, Hunter, David J., Thomas, Gilles, Hirschhorn, Joel N., Abecasis, Goncalo, Altshuler, David, Bailey-Wilson, Joan E., Brooks, Lisa D., Cardon, Lon R., Daly, Mark, Donnelly, Peter, Fraumeni, Joseph F., Freimer, Nelson B., Gerhard, Daniela S., Gunter, Chris, Guttmacher, Alan E., and Guyer, Mark S.
- Subjects
PHENOTYPES ,PROTEOMICS ,MOLECULAR biology ,GENETICS ,GENETIC mutation ,REPLICATION (Experimental design) - Abstract
The article presents a replication study that evaluates the previous study on genotype-phenotype associations. The study concentrates on the initial discoveries which limit the plethora of false-positive results and determines the valid associations of genotype-phenotype. Three topics were addressed by the investigators, including the assessment of the validity and limitations of any genetic association, criteria for establishing the replication, and publication of high-quality association.
- Published
- 2007
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