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Reports on the discovery of a new gene located at the inversion of embryonic turning (inv) locus. How most vertebrate internal organs show a distinctive left/right asymmetry; Expression of the gene seen as being the highest in the kidneys and liver among adult tissues, and is seen in presomite-stage embryos; Findings suggesting that transgenic introduction of a minigene encoding the candidate protein restores normal left/right asymmetry and kidney development in the inv mutant.

Describes a member of the transforming growth factor-beta family called the lefty gene which may encode a morphogen for L-R determination. Examples of lateral asymmetry in vertebrates; Molecular mechanism governing the establishment of left-right handedness; Expression of the lefty gene in the left half of gastrulating mouse embryos; Period of appearance.