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1. Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art.

Author

Zinellu, Angelo, Fois, Alessandro G., Mangoni, Arduino A., Paliogiannis, Panagiotis, Sotgiu, Elisabetta, Zinellu, Elisabetta, Marras, Viviana, Pirina, Pietro, and Carru, Ciriaco

Subjects
*ASYMMETRIC dimethylarginine, *METHYLATION, *OBSTRUCTIVE lung diseases, *NITRIC oxide, *BIOLOGICAL fluid dynamics
Abstract

Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area. [ABSTRACT FROM AUTHOR]

Published
2018
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