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This paper shows the results of a study aimed at quantitatively estimating—in terms of direct (repair) costs, at large scale (1:5000)—the slow-moving landslide risk to a road network assumed as undamaged as well as the consequences to the same network in damaged conditions. The newly conceived methodological approaches address some challenging tasks concerning (i) the hazard analysis, which is expressed in terms of probability of occurrence of slow-moving landslides with a given intensity level that, in turn, is established based on empirical fragility curves, and (ii) the consequence analysis, which brings to the generation of time-dependent vulnerability curves. Their applicability is successfully tested in a case study in the Campania region (southern Italy) for which both very high-resolution DInSAR data and information gathered from in situ surveys on the severity of damage sustained by the selected road sections are available. Benefits associated with the use of the obtained results in informed decision-making processes are finally discussed. [ABSTRACT FROM AUTHOR]