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This article, published in the Chemistry of Natural Compounds journal, explores the use of the OSMAC strategy to enhance the diversity and yield of bioactive compounds from the endophytic fungus Xylaria sp. GDG-102. The fungus was cultivated in a rice medium with monosodium glutamate, resulting in the isolation of nine compounds with antibacterial properties against various bacteria. The article also presents crystal data for one of the compounds, (αR)-3-chloro-α,4-dihydroxybenzeneacetamide, for the first time. The text provides detailed information about the chemical properties of these compounds, including their molecular formulas, physical characteristics, and nuclear magnetic resonance (NMR) spectra. The research received support from the National Natural Science Foundation of China and the Guangxi Natural Science Foundation of China. [Extracted from the article]

Secondary metabolites from the genus I Metarhizium i yielded several bioactive compounds, such as metarhiziumoids A and B showed glycosidase inhibitory activity [[3]], omalvin A displayed antibacterial activity [[4]], and destruxin A exhibited phytotoxic activity [[5]]. I Metarhizium marquandii i is an endophytic fungus isolated from the Chinese medicinal plant I Sophora tonkinensis i (Leguminosae) I . i In our ongoing search for biologically active compounds from fungi [[6]-[9]], the metabolites of I M. marquandii i were investigated. At the concentration of 100 g/mL, compound B 2 b showed antifungal activity to all five fungi. Graph Compounds B 1-5 b were evaluated for their antifungal activities against five phytopathogenic fungi, I Alternaria alternaria i , I Alternaria cabbage i , I Cochliobolus miyabeanus i , I Colletotrichum capsici i , I Ceratocystis paradoxa i , using a modified version of the 2-fold serial dilutions method [[15]]. [Extracted from the article]

Herein, we report on the isolation and anti-inflammatory activities of these compounds. Compound B 6 b showed significant anti-inflammatory activity by inhibiting the production of NO in LPS-induced RAW 264.7 cells with IC SB 50 sb value of 23.24 ± 1.3 M (indomethacin IC SB 50 sb 33.50 ± 1.13 M), the other compounds showed no obvious anti-inflammatory activity ( B 1-5 b , IC SB 50 sb > 50 M). Among them, compound B 4 b was isolated from genus I Xylaria i firstly I , i and the other compounds were isolated from I Xylaria grammica i for the first time. Graph All compounds were tested for their anti-inflammatory activities [[4], [20]]. [Extracted from the article]