1. Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study.
- Author
-
Gomes, Bruna, Hedman, Kristofer, Kuznetsova, Tatiana, Cauwenberghs, Nicholas, Hsu, David, Kobayashi, Yukari, Ingelsson, Erik, Oxborough, David, George, Keith, Salerno, Michael, Ashley, Euan, and Haddad, Francois
- Subjects
- *
LEAN body mass , *VENTRICULAR remodeling , *DUAL-energy X-ray absorptiometry , *ALLOMETRY , *FAT - Abstract
Purpose: The geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and concentricity, most often measured using the mass-to-volume ratio (MVR). The aims of this study were to validate lean body mass (LBM)-based allometric coefficients for scaling and to determine an index of concentricity that is independent of both volume and LBM. Methods: Participants from the UK Biobank who underwent both CMR and dual-energy X-ray absorptiometry (DXA) during 2014–2015 were considered (n = 5064). We excluded participants aged ≥ 70 years or those with cardiometabolic risk factors. We determined allometric coefficients for scaling using linear regression of the logarithmically transformed ventricular remodeling parameters. We further defined a multiplicative allometric relationship for LV concentricity (LVC) adjusting for both LVEDV and LBM. Results: A total of 1638 individuals (1057 female) were included. In subjects with lower body fat percentage (< 25% in males, < 35% in females, n = 644), the LBM allometric coefficients for scaling LVM and LVEDV were 0.85 ± 0.06 and 0.85 ± 0.03 respectively (R2 = 0.61 and 0.57, P < 0.001), with no evidence of sex–allometry interaction. While the MVR was independent of LBM, it demonstrated a negative association with LVEDV in (females: r = − 0.44, P < 0.001; males: − 0.38, P < 0.001). In contrast, LVC was independent of both LVEDV and LBM [LVC = LVM/(LVEDV0.40 × LBM0.50)] leading to increased overlap between LV hypertrophy and higher concentricity. Conclusions: We validated allometric coefficients for LBM-based scaling for CMR indexed parameters relevant for classifying geometric patterns of ventricular remodeling. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF