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This editorial introduces to a Special Issue of Environmental Science and Pollution Research, highlighting selected papers presented at the international symposium on "The Fourth International Conference on Materials and Environmental Science (ICMES2020)", is organized by Mohammed Premier University, Faculty of Science, Oujda Morocco, and the Association: Moroccan Center for Sciences Development-MOCEDES. Modeling and numerical simulation of the chip formation process when machining Nomex Effect of n-amyl alcohol/biodiesel blended nano additives on the performance, combustion and emission characteristics of CRDI diesel engine An experimental assessment on the influence of high fuel injection pressure with ternary fuel (diesel-mahua methyl ester-pentanol) on performance, combustion and emission characteristics of common rail direct injection diesel engine Reuse of treated wastewater and non-potable groundwater in the manufacture of concrete: major challenge of environmental preservation Temperature and extraction methods effects on yields, fatty acids and tocopherols of prickly pear ( I OPUNTIA FICUSÊINDICAÊL i .) In detail, 8 communications on material and environmental science: Influence of the effect of nanoparticle additives blended with mahua methyl ester on performance, combustion and emission characteristics of CRDI diesel engine COVID-19: unbalanced management of occupational risks case of the analysis of the chemical risk related to the use of disinfectants in the dairy industry in Morocco. [Extracted from the article]

Ectopic expression of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse melanocytes induces melanoma formation. Although requirement of mGluR1 for development of melanoma in the initial stage has been demonstrated, its role in melanoma growth in vivo remains unclear. In this study, we developed novel transgenic mice that conditionally express mGluR1 in melanocytes, using a tetracycline regulatory system. Pigmented lesions on the ears and tails of the transgenic mice began to appear 29 weeks after activation of the mGluR1 transgene, and the transgenic mice produced melanomas at a frequency of 100% 52 weeks after transgene activation. Subsequent inactivation of the mGluR1 transgene in melanoma-bearing mice inhibited melanoma growth with reduction of immunoreactivity to phosphorylated ERK1/2, whereas mice with persistent expression of mGluR1 developed larger melanoma burdens. mGluR1 expression is thus required not only for melanoma development but also for melanoma growth in vivo. These findings suggest that growth of melanoma can be inhibited in vivo by eliminating only one of the multiple genetic anomalies involved in tumorigenesis.Oncogene (2008) 27, 7162–7170; doi:10.1038/onc.2008.329; published online 8 September 2008 [ABSTRACT FROM AUTHOR]

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