1. The non-coding RNA interactome in joint health and disease.
- Author
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Ali, Shabana A., Peffers, Mandy J., Ormseth, Michelle J., Jurisica, Igor, and Kapoor, Mohit
- Subjects
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NON-coding RNA , *JOINTS (Anatomy) , *OSTEOARTHRITIS , *JOINT diseases , *LINCRNA , *CIRCULAR RNA , *JOINT physiology , *INFLAMMATION treatment , *RNA physiology , *INFLAMMATION , *RNA , *GENES , *RHEUMATOID arthritis , *GENOMICS , *RESEARCH funding - Abstract
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput profiling studies and mechanistic investigations of microRNAs, long non-coding RNAs and circular RNAs in joint tissues and biofluids has increased, data have emerged that suggest complex interactions among non-coding RNAs that are often overlooked as critical regulators of gene expression. Identifying these non-coding RNAs and their interactions is useful for understanding both joint health and disease. Non-coding RNAs regulate signalling pathways and biological processes that are important for normal joint development but, when dysregulated, can contribute to disease. The specific expression profiles of non-coding RNAs in various disease states support their roles as promising candidate biomarkers, mediators of pathogenic mechanisms and potential therapeutic targets. This Review synthesizes literature published in the past 2 years on the role of non-coding RNAs in OA and RA with a focus on inflammation, cell death, cell proliferation and extracellular matrix dysregulation. Research to date makes it apparent that 'non-coding' does not mean 'non-essential' and that non-coding RNAs are important parts of a complex interactome that underlies OA and RA. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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