1. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.
- Author
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Hobeika, Elias, Levit‐Zerdoun, Ella, Anastasopoulou, Vasiliki, Pohlmeyer, Roland, Altmeier, Simon, Alsadeq, Ameera, Dobenecker, Marc‐Werner, Pelanda, Roberta, and Reth, Michael
- Subjects
CD19 antigen ,B cells ,PROTEIN-tyrosine kinases ,ANTIGEN receptors ,LYMPHOCYTES - Abstract
The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B-cell antigen receptor ( BCR). The spleen tyrosine kinase (Syk) plays a central role in the activation of the BCR, but less is known about its contribution to the survival and maintenance of mature B cells. We generated mice with an inducible and B-cell-specific deletion of the Syk gene and found that a considerable fraction of mature Syk-negative B cells can survive in the periphery for an extended time. Syk-negative B cells are defective in BCR, RP105 and CD38 signaling but still respond to an IL-4, anti- CD40, CpG or LPS stimulus. Our in vivo experiments show that Syk-deficient B cells require BAFF receptor and CD19/ PI3K signaling for their long-term survival. These studies also shed a new light on the signals regulating the maintenance of the normal mature murine B-cell pool. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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