1. Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall
- Author
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Ines Carloni, Andrea Quarti, Marco Pozzi, Fernando Maria de Benedictis, Stefano Gasparini, Massimo Colaneri, Colaneri M., Quarti A., Pozzi M., Gasparini S., Carloni I., and De Benedictis F.M.
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Heart disease ,medicine.medical_treatment ,Case Report ,Plastic bronchitis ,Respiratory Mucosa ,Tissue plasminogen activator ,Diagnosis, Differential ,Fontan procedure ,Plastic bronchiti ,Primary ciliary dyskinesia ,Administration, Inhalation ,Bronchoscopy ,medicine ,Humans ,Respiratory system ,Bronchitis ,Respiratory distress ,business.industry ,Nebulizers and Vaporizers ,medicine.disease ,Surgery ,Microscopy, Electron ,Complication ,business ,Follow-Up Studies ,medicine.drug - Abstract
Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated. © 2014 Colaneri et al.; licensee BioMed Central Ltd.
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