1. Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
- Author
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Lotta, Luca, Pietzner, Maik, Stewart, Isobel, Wittemans, Laura BL, Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma, Oliver-Williams, Clare, Auyeung, Victoria PW, Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory, Scott, Robert, Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita, Khaw, Kay-Tee, Griffin, Julian, Wood, Angela, Kastenmüller, Gabi, Danesh, John, Butterworth, Adam, Gribble, Fiona, Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas, Langenberg, Claudia, MacTel Consortium, Forouhi, Nita [0000-0002-5041-248X], Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], Langenberg, Claudia [0000-0002-5017-7344], and Apollo - University of Cambridge Repository
- Subjects
MacTel Consortium ,health care economics and organizations - Abstract
Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across six cohorts including up to 86,507 participants (70% unpublished data), we identify 499 (362 novel) genome-wide significant associations (p
- Published
- 2020