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Background: The incidence of obesity in African Americans (AAs) is higher than in non-AA in the USA. Previous studies using large national databases report that AA patients have worse outcomes than non-AA patients. Objectives: To assess perioperative outcomes among AA patients after MBS at a center of excellence (COE) that serves a large, diverse patient population. Setting: University Hospital Methods: A retrospective analysis was performed on patients undergoing MBS between 2010 and 2020 at our two accredited MBSAQIP (Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program) COEs where the AA population makes up over 35% of the population. Preoperative variables were compared using unpaired t-test or chi-squared test where appropriate. Thirty-day outcomes were compared following propensity score matching (exact algorithm) of demographics and comorbidities. Results: Overall, 5742 patients (AA = 2058, 36%) had Roux-en-Y gastric bypass (AA = 1028, 26%) or sleeve gastrectomy (AA = 1030, 27%). AA patients were more often female (90.2% vs. 80.2%, p < 0.001) and had higher rates of hypertension (56.3% vs. 47.8%, p < 0.001), while non-AA patients had higher rates of hyperlipidemia (27.3% vs. 20.7%, p < 0.001) and obstructive sleep apnea (41.2% vs. 37.1%, p = 0.0024). Matched data showed that AA patients had higher rates of pulmonary embolism (PE) (0.3% vs. 0.1%, p = 0.020) and more emergency department visits (7.0% vs. 5.1%, p = 0.012) but no differences in mortality, readmission, reintervention, or reoperation rates. Conclusions: In a diverse area, AA patients who underwent MBS had similar perioperative outcomes compared to non-AA patients except that they experienced higher rates of PE. They also experienced higher rates of emergency department visits but had similar readmission rates. [ABSTRACT FROM AUTHOR]

Despite several decades of development, microfluidics lacks a sealing material that can be readily fabricated, leak-tight under high liquid water pressure, stable over a long time, and vacuum compatible. In this paper, we report the performances of a micro-scale processable sealing material for nanofluidic/microfluidics chip fabrication, which enables us to achieve all these requirements. We observed that micrometric walls made of SU-8 photoresist, whose thickness range from 35 to 135 µm, are at least leak-tight to 1.5 bars and up to 5.5 bars, exhibit no water porosity even after 2 months of aging, and are able to sustain under 10 - 5 mbar vacuum. This sealing material is therefore reliable and versatile for building microchips, part of which must be isolated from liquid water under pressure or vacuum. Moreover, the fabrication process we propose does not require the use of either aggressive chemicals or high-temperature or high-energy plasma treatment. It thus opens a new perspective to seal microchips with sensitive surfaces containing nanomaterials. [ABSTRACT FROM AUTHOR]

Background: Freestanding emergency departments (FSEDs) have generated improved hospital metrics, including decreased ED wait times and increased patient selection. Patient outcomes and process safety have not been evaluated. This study investigates the safety of FSED virtual triage in the emergency general surgery (EGS) patient population. Methods and procedures: A retrospective review evaluated all adult EGS patients admitted to a community hospital between January 2016 and December 2021 who either presented at a FSED and received virtual evaluation from a surgical team (fEGS) or presented at the community hospital emergency department and received in-person evaluation from the same surgical group (cEGS). Patients' demographics, acute care utilization history, and clinical characteristics at the onset of the index visit were used to build a propensity score model and stabilized Inverse Probability of Treatment Weights (IPTW) were used to create a weighted sample. Multivariable regression models were then employed to the weighted sample to evaluate the treatment effect of virtual triage compared to in-person evaluation on short-term outcomes, including length of stay (LOS) and 30-day readmission and mortality. Variables which occurred during the index visit (such as surgery duration and type of surgery) were adjusted for in the multivariable analyses. Results: Of 1962 patients, 631 (32.2%) were initially evaluated virtually (fEGS) and 1331 (67.8%) underwent an in-person evaluation (cEGS). Baseline characteristics demonstrated significant differences between the cohorts in gender, race, payer status, BMI, and CCI score. Baseline risks were well balanced in the IPTW-weighted sample (SD range 0.002–0.18). Multivariable analysis found no significant differences between the balanced cohorts in 30-day readmission, 30-day mortality, and LOS (p > 0.05 for all). Conclusion: Patients who undergo virtual triage have similar outcomes to those who undergo in-person triage for EGS diagnoses. Virtual triage at FSED for these EGS patients may be an efficient and safe means for initial evaluation. [ABSTRACT FROM AUTHOR]

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair factors, Polθ function is activated in mitosis upon phosphorylation by Polo-like kinase 1 (PLK1). Phosphorylated Polθ is recruited by a direct interaction with the BRCA1 C-terminal domains of TOPBP1 to mitotic DSBs, where it mediates joining of broken DNA ends. Loss of Polθ leads to defective repair of mitotic DSBs, resulting in a loss of genome integrity. This is further exacerbated in cells that are deficient in homologous recombination, where loss of mitotic DSB repair by Polθ results in cell death. Our results identify mitotic DSB repair as the underlying cause of synthetic lethality between Polθ and homologous recombination. Together, our findings reveal the critical importance of mitotic DSB repair in the maintenance of genome integrity.In mitosis, genome integrity is maintained by DNA polymerase theta-dependent repair of DNA double-strand breaks, which is regulated by Polo-like kinase 1 activity. [ABSTRACT FROM AUTHOR]

Introduction: Biliopancreatic diversion with duodenal switch (BPD-DS) has often been reserved for patients with BMI > 50 kg/m2. We aim to assess the safety of BPD-DS in patients with morbid obesity (BMI 335 kg/m2 and < 50 kg/m2) using a 150-cm common channel (CC), 150-cm Roux limb, and 60-fr bougie. Methods: A retrospective review was performed on patients with a BMI < 50 mg/k2 who underwent a BPD-DS in 2016–2019 at a single institution. Limb lengths were measured with a laparoscopic instrument with minimal tension. Sleeve gastrectomy was created with 60-fr bougie. Variables were compared using paired t test, Chi-square analysis or repeated measures ANOVA where appropriate. Results: Forty-five patients underwent BPD-DS. CC lengths and Roux limb lengths were 158 ± 20 cm and 154 ± 18 cm, respectively. Preoperative BMI was 44.9 ± 2.3 kg/m2 and follow-up was 2.7 ± 1.4 years. One patient required reoperation for bleeding and died from multiorgan failure and delayed sleeve leak. There was 1 (2.2%) readmission for contained anastomotic leak and 2 ED visits (4.5%) within 30 days. There were no marginal ulcers, limb length revisions, or need for parental nutrition. Percent excess weight loss was 67.2 ± 19.7%. 88.9% (N = 8), 86.6% (N = 13), and 55.5% (N = 5) of patients had resolution or improvement of their diabetes mellitus type II, hypertension, and hyperlipidemia, respectively. 40% (N = 4) of patients had resolution of their gastroesophageal reflux disease (GERD) and 11.4% (N = 5) developed de novo GERD. 32% (N = 14) of patients had vitamin D deficiency and 25% (N = 11) experienced zinc deficiency. Conclusion: BPD-DS may be considered in patients with BMI < 50 kg/m2 with 150-cm CC, 150-cm Roux limb, and a 60-fr bougie sleeve gastrectomy. There was sustained weight loss and no protein calorie malnutrition, but Vitamin D and zinc deficiency remained a challenge. Careful patient selection and proper counseling of the risks and benefits are necessary. [ABSTRACT FROM AUTHOR]

Evaluation and potential certification by analysis (CBA) has emerged as a promising tool to reduce costly crashworthiness tests of prototype, by using physics-based simulation and analysis. One of the major obstacles in the CBA implementation for vehicle crashworthiness certification is the discrepancy between computer-aided engineering (CAE) model prediction and the actual response of vehicle crash tests. This paper aims to improve the prediction accuracy of the crashworthiness CAE model under new test speed by fusing CAE data and a small number of crash test data using machine learning models. Two novel approaches are developed in the time domain and the displacement domain to achieve the goal of data fusion for the correction of the CAE model. More specifically, in the time domain (time vs. deceleration), a low-fidelity temporal convolutional network (TCN) is first trained using a large volume of simulation data generated from a CAE model. The low-fidelity TCN model is then fine-tuned to a multi-fidelity TCN through transfer learning using a small number of test data. In the displacement domain (displacement vs. deceleration), the deceleration response as a function of time is first converted into a function of displacement. A Gaussian process regression (GPR) model is then utilized to capture the model bias of the nonlinear spring constant under a dynamic analysis scheme. The learned GPR model finally is integrated into vehicle deceleration dynamic analysis along with the original CAE model to predict vehicle deceleration under a new crash speed. A real-world case study of vehicle crash tests is employed to validate the proposed two approaches. The results show that both proposed approaches in general can recover model bias of the CAE model and give a noticeable improvement in CAE model prediction accuracy. [ABSTRACT FROM AUTHOR]

Background: Obesity rates in Hispanics and African Americans (AAs) are higher than in Caucasians in the USA, yet the rate of metabolic and bariatric surgery (MBS) for weight loss remains lower for both Hispanics and AAs. Methods: Patient demographics and outcomes of adult AA and Hispanic patients undergoing sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) procedures were analyzed using the MBSAQIP dataset [2015–2018] using unmatched and propensity-matched data. Results: In total, 173,157 patients were included, of whom 98,185 were AA [56.7%] [21,163-RYGB; 77,022-SG] and 74,972 were Hispanic [43.3%] [20,282-RYGB; 54,690-SG]). Preoperatively, the AA cohort was older, had more females, and higher BMIs with higher rates of all tracked obesity-related medical conditions except for diabetes, venous stasis, and prior foregut surgery. Intra- and postoperatively, AAs were more likely to experience major complications including unplanned ICU admission, 30-day readmission/reintervention, and mortality. After propensity matching, the differences in ED visits, treatment for dehydration, 30-day readmission, 30-day intervention, and pulmonary embolism remained for both SG and RYGB cohorts. Progressive renal insufficiency and ventilator use lost statistical significance in both cohorts. Conversely, 30-day reoperation, postoperative ventilator requirement, unplanned intubation, unplanned ICU admission, and mortality lost significance in the RYGB cohort, but not SG patients. Conclusion: Outcomes for AA patients were worse than for Hispanic patients, even after propensity matching. After matching, differences in major complications and mortality lost significance for RYGB, but not SG. These data suggest that outcomes for RYGB may be driven by the presence and severity of pre-existing patient-related factors. [ABSTRACT FROM AUTHOR]

This article proposes an advanced nonlinear soil-structure interaction methodology, for the seismic analysis of a nuclear structure. To do so, a study is performed on a nuclear reinforced concrete structure considering the effects of the nonlinearity due to the sliding and rocking at the soil-structure interface, under a Beyond Design Basis Earthquake. A tridimensional numerical model based on the Finite Element Method is developed for the structure and the soil. The model of the structure considers composite materials to describe all the structural members, taking full advantage of the modelling capabilities of the finite element method. The soil layers are modelled assuming their degraded properties due to the propagation of the seismic ground motion. An innovative approach to achieve spectral matching at the surface of the FEM soil model after propagation from the bedrock has been successfully implemented. The seismic analysis on the structure has been performed by considering three hypotheses for the contact between soil and structure: fixed-base, fixed contact and sliding-rocking contact. Insights are provided after comparing floor spectra for the contact approaches assessed in this research, calculated at the systems and components’ locations at the nuclear structure. Finally, a statistical approach for the soil properties allows to study the effects of these uncertainties on the structural response. [ABSTRACT FROM AUTHOR]

Introduction: For patients with super obesity (BMI > 50 kg/m2), biliopancreatic diversion/duodenal switch (BPD/DS) can be an effective bariatric operation. Technical challenges and patient safety concerns, however, have limited its use as a primary procedure. This study sought to assess the safety of primary versus revisional BPD/DS. Materials and Methods: The MBSAQIP database was queried for primary and revisional BPD/DS (2015–2018). Inclusion criteria were patients ≥ 18 years of age, BMI > 50 kg/m2, and with no concurrent procedures. Preoperative variables were compared using a chi-square test or Wilcoxon two-sample tests. Multivariate logistic or robust linear regression models were used to compare outcomes. Results: There were 3,378 primary BPD/DS and 487 revisional BPD/DS patients. Primary BPD/DS patients had higher BMI (56.5 [IQR4.4] versus 54.8 [IQR4] kg/m2, p < 0.0001) and had more diabetes mellitus type II (29.1% versus 17.2%, p < 0.0001). Intraoperatively, revisional BPD/DS had longer operative time (165 [IQR47] min versus 139 [IQR100] min, p < 0.0001). After adjusting for preoperative characteristics, there was no difference in 30-day readmission or ED visits (primary 12.9% versus revisional 14.6%), reoperation or reintervention (primary 5.7% versus revisional 7.8%), or mortality (primary 0.4% versus revisional 0.6%). In contrast, the revisional BPD/DS patients had higher odds of major morbidity (primary 3.4% versus revisional 5.3%, OR 1.9, CI 1.1–3.2, p = 0.019). Conclusions: Revisional BPD/DS is associated with higher morbidity than primary BPD/DS in patients with super obesity. These patients should thus be counselled appropriately when choosing a primary or revisional bariatric procedure. [ABSTRACT FROM AUTHOR]

In this work, a critical comparison between three different numerical approaches for the computational modelling of quasi-brittle structural failure is presented. Among the many finite element approaches devised to solve the problem, both using continuous and discontinuous methods, the present study examines the relative performance of the XFEM, the mixed strain/displacement FE and phase-field models. These numerical techniques are selected as the current representatives of embedded, smeared and regularized models for analyzing the phenomenon of fracture with different mathematical descriptions for the cracking induced discontinuities in the displacement and strain fields. The present investigation focusses on the main differences of the formulation of these models both at the continuum and discrete level and discusses the main assets and burdens that ensue in their practical application. The relative advantages and difficulties related to their use in the computation of localized structural failure in engineering practice are evaluated against a 10-point checklist that cover the main challenges met by these models. The paper includes an extensive comparison of selected numerical benchmark problems analyzed with the three examined methods. Relative performance is assessed in terms of load capacity, force–displacement curves, crack paths, collapse mechanisms, cost-efficiency and other key issues. [ABSTRACT FROM AUTHOR]

Purpose: Marginal ulceration (MU) is a common long-term complication following Roux-en-Y gastric bypass (RYGB). The causes of MU after RYGB are multifactorial and include surgical technique of constructing the gastrojejunal anastomosis (GJA). The purpose of this study is to evaluate the relationship between gastric pouch size in RYGB and MU using CT volumetrics. Material and Methods: Patients were retrospectively identified who underwent esophagogastroduodenoscopy (EGD) following RYGB at a tertiary care teaching hospital. Measurement of gastric pouch size was performed using 3-D CT software. Standard statistical methods were used, a univariate comparison was performed between MU and non-MU patients followed by a propensity-matched comparison to control for factors known to affect MU, and a propensity-matched subgroup analysis was also performed. Results: In total, 122 patients met criteria, 57 of which had MU on EGD and 65 who did not. The MU group had more smokers and patients with PPI use than the non-MU group, and the mean time from operation to CT scan was 26.6 months (range: 0–108 months). The MU group had a larger gastric pouch size than the non-MU group (34.1 ± 11.8 versus 20.1 ± 6.8 cm3). When analyzed for matched patient cohorts, this difference remained for the MU group that included smokers and PPI use. When stratified for pouch size, for each 5 cm3 increase in pouch size, patients had 2.4 times odds increase of MU formation. Conclusions: CT volumetric analysis demonstrated that a larger gastric pouch size was associated with MU following RYGB. [ABSTRACT FROM AUTHOR]

There are personal and institutional decisions that can increase the seismic resilience of the buildings in a city. However, some of these decisions are possible if we have basic knowledge of buildings' seismic risk. The present document describes the main results of a detailed study of seismic vulnerability and seismic risk of residential buildings of Ciutat Vella (the ancient district of Barcelona) and Nou Barris (one of the newest districts of Barcelona). In this study, we assessed seismic risk according to the Vulnerability Index Method-Probabilistic named as VIM_P. Moreover, we analyzed the influence of basic buildings' features in the final vulnerability and seismic risk values. For instance, we assessed the seismic vulnerability and the seismic risk of groups of buildings defined according to the number of stories of the buildings. Findings of this research reveal that the annual frequency of exceedance of the collapse damage state in Ciutat Vella buildings is, on average, 4.7 times higher than for the buildings in Nou Barris. Moreover, according to the Best vulnerability curve, 70.31% and 2.81% of Ciutat Vella and Nou Barris buildings, respectively, have an annual frequency of exceedance of the collapse damage state greater than 1 × 10–5. [ABSTRACT FROM AUTHOR]

Purpose: Patients undergoing laparoscopic Roux-en-Y gastric bypass (RYGB) are at risk of developing strictures of the gastrojejunal anastomosis (GJA). Several variables can affect this, one of which may be the method of anastomosis. Between 2010 and 2014, our institution utilized three different anastomotic techniques for creating the GJA (25 mm end-to-end circular-stapled (CS), linear-stapled (LS), and robotic hand sewn (HS)). Our objectives were to compare the method of GJA relative to the subsequent development of anastomotic stricture. Methods: We queried our electronic health record for all patients who underwent an upper endoscopy (EGD) after RYGB (2010–2014). Patient charts were retrospectively reviewed for type of GJA, weight loss, complications, interventions, and revisions of the GJA. Results: In total, 1112 RYGB were performed at our institute, and 17.4% of patients (194/1112) had an upper endoscopy (EGD). Overall, 3.1% (34/1112) were found to have a stricture of the GJA. Patients undergoing a CS, LS, and HS anastomosis had GJA stricture rates of 4.9%, 0.5%, and 1.2% respectively (CS to LS (p < 0.05), p = NS among CS vs. HS, and LS vs. HS). The rate of GJA revision was 1.5%, 0.5%, and 0.1% (p = NS). In patients who had an EGD, excess BMI loss was 57.4%, 64.6%, and 59.2% (p = NS). In patients symptomatic from strictures, excess BMI loss was 69.4%, 83%, and 63.5% respectively (p = NS). Conclusion: The anastomotic technique for creating of the GJA may impact the formation of strictures. Based on our experience, gastrojejunostomies created with a 2-mm EEA-stapling technique are at higher risk of strictures. [ABSTRACT FROM AUTHOR]

Brain tissue deformation resulting from head impacts is primarily caused by rotation and can lead to traumatic brain injury. To quantify brain injury risk based on measurements of kinematics on the head, finite element (FE) models and various brain injury criteria based on different factors of these kinematics have been developed, but the contribution of different kinematic factors has not been comprehensively analyzed across different types of head impacts in a data-driven manner. To better design brain injury criteria, the predictive power of rotational kinematics factors, which are different in (1) the derivative order (angular velocity, angular acceleration, angular jerk), (2) the direction and (3) the power (e.g., square-rooted, squared, cubic) of the angular velocity, were analyzed based on different datasets including laboratory impacts, American football, mixed martial arts (MMA), NHTSA automobile crashworthiness tests and NASCAR crash events. Ordinary least squares regressions were built from kinematics factors to the 95% maximum principal strain (MPS95), and we compared zero-order correlation coefficients, structure coefficients, commonality analysis, and dominance analysis. The angular acceleration, the magnitude and the first power factors showed the highest predictive power for the majority of impacts including laboratory impacts, American football impacts, with few exceptions (angular velocity for MMA and NASCAR impacts). The predictive power of rotational kinematics about three directions (x: posterior-to-anterior, y: left-to-right, z: superior-to-inferior) of kinematics varied with different sports and types of head impacts. [ABSTRACT FROM AUTHOR]

Background: Marginal ulceration (MU) and bleeding are possible complications following laparoscopic Roux-en-Y gastric bypass (RYGB). Our institution utilizes three techniques for performing the gastrojejunal anastomosis (GJA), providing a means to compare postoperative MU and bleeding as it relates to GJA technique. Objectives: We sought to analyze the incidence of MU and bleeding between the 25-mm end-to-end anastomosis (EEA) stapler, linear stapler (LS), and robotic hand-sewn (RHS) GJA techniques. Methods: Electronic health records for all patients who had an upper endoscopy (EGD) after RYGB were queried (2010–2014). Charts were retrospectively reviewed for type of GJA, complications, endoscopic interventions, and smoking and NSAID use. Results: Out of 1112 RYGBs, the GJA was created using an EEA, LS, or RHS approach in 58.6%, 33.6%, and 7.7% of patients, respectively. 17.4% had an EGD (19.9% EEA, 13.9% LS, and 14.0% RHS). Incidence of MU was 7.3% (9.3% EEA, 4.8% LS, and 5.8% RHS). Rates of EGD and MU were significantly higher after EEA vs. LS GJA (p<0.05). The bleeding rate was 1.5%, [1.1% EEA, 2.1% LS, and 2.3% RHS (p=NS)]. MU within 90 days of RYGB occurred in 4.1%, 0.8%, and 4.7%, respectively (p<0.05 for EEA vs LS only). NSAID and cigarette use were identified in 29.3%, 38.9%, and 60% and 17.2%, 22.2%, and 20%, respectively, for the EEA, LS, and RHS GJA (p=NS). Conclusion: The method of GJA has an impact on rate of MU formation. A GJA fashioned with a 25-mm EEA stapler tends to have higher rates of EGD and MU. [ABSTRACT FROM AUTHOR]

Background: The incidence of obesity is disproportionally high in African Americans (AA) in the United States. This study compared outcomes for AA patients undergoing Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) with non-AA patients. Methods: The MBSAQIP database was reviewed for RYGB and SG patients (2015–2017). Patients were identified as AA or non-AA and grouped to RYGB or SG. Combined and univariate analyses were performed on unmatched/propensity matched populations to assess outcomes. Results: After applying exclusion criteria, 75,409 AA and 354,305 non-AA patients remained. Univariate analysis identified AA-RYGB and AA-SG patients were heavier and younger than non-AA patients. Overall, AA patients tended to have fewer preoperative comorbidities than non-AA patients with the majority of AA comorbidities related to hypertension and renal disease. Analysis of propensity matched data confirmed AA bariatric surgery patients had increased cardiovascular-related disease incidence compared with non-AA patients. Perioperatively, AA-RYGB patients had longer operative times, increased rates of major complications/ICU admission, and increased incidence of 30-day readmission, re-intervention, and reoperation, concomitant with lower rates of minor complications/superficial surgical site infection (SSI) compared with non-AA patients. For SG, AA patients had longer operative times and higher rates of major complications and 30-day readmission, re-intervention, and mortality, coupled with fewer minor complications, superficial/organ space SSI, and leak. Conclusion: African American patients undergoing bariatric surgery are younger and heavier than non-AA patients and present with different comorbidity profiles. Overall, AAs exhibit worse outcomes following RYGB or SG than non-AA patients, including increased mortality rates in AA-SG patients. [ABSTRACT FROM AUTHOR]

Background: Bariatric surgery is the most effective modality to treat obesity and obesity-related comorbidities. This study sought to utilize the MBASQIP® Data Registry to analyze the impact of age at time of surgery on outcomes following sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) procedures.Methods: The MBSAQIP® Data Registry for patients undergoing SG or RYGB procedures between 2015 and 2016 was reviewed. Patients were divided into 4 age groups [18-44; 45-54; 55-64; > 65 years]. Minimal exclusions for revisional and/or emergency surgery were selected and combination variables created to classify complications as major or minor. A comorbidity index was constructed to include diabetes, gastroesophageal reflux disease (GERD), obstructive sleep apnea (OSA), and prior cardiac surgery. Univariate and multivariate logistic regression analyses were performed to compare age stratifications to the young adult (18-45 years) cohort.Results: Of 301,605 cases, 279,419 cases (71.2% SG) remained after applying exclusion criteria (79.2% female, mean BMI 45.5 ± 8.1 kg/m2, 8.9% insulin-dependent diabetics). Mean age was 44.7 ± 12.0 years (51.3% 18-44 years; 26.9% 45-54 years; 16.3% 55-64 years; 5.5% > 65 years). A univariate analysis demonstrated preoperative differences of lower BMI with increasing age concomitant with increasing frequency of RYGB and a higher comorbidity index (p < 0.0001 vs. 18-45 years). At age > 45 years, major complications and 30-day mortality increased independent of procedure type (p < 0.0001). A multivariate analysis controlling for comorbidity indices demonstrated increasing age (> 45 years) increased risk for major complications and mortality.Conclusion: Overall, bariatric surgery (SG or RYGB) remains a low mortality risk procedure for all age groups. However, all age group classifications > 45 years had higher incidence of major complications and mortality compared to patients 18-45 years (despite older individuals having lower preoperative BMI) indicating delaying surgery is detrimental. [ABSTRACT FROM AUTHOR]

Background: Male patients undergoing bariatric surgery have (historically) been considered higher risk than females. The aim of this study was to examine the disparity between genders undergoing laparoscopic sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (RYGB) procedures and assess gender as an independent risk factor. Methods: The MBSAQIP® Data Registry Participant User Files for 2015–2017 was reviewed for patients having primary SG and RYGB. Patients were divided into groups based on gender and procedure. Variables for major complications were grouped together, including but not limited to PE, stroke, and MI. Univariate and propensity matching analyses were performed. Results: Of 429,664 cases, 20.58% were male. Univariate analysis demonstrated males were older (46.48 ± 11.96 vs. 43.71 ± 11.89 years, p < 0.0001), had higher BMI (46.58 ± 8.46 vs. 45.05 ± 7.75 kg/m2, p < 0.0001), and had higher incidence of comorbidities. Males had higher rates of major complications (1.72 vs. 1.05%; p < 0.0001) and 30-day mortality (0.18 vs. 0.07%, p < 0.0001). Significance was maintained after subgroup analysis of SG and RYGB. Propensity matched analysis demonstrated male gender was an independent risk factor for RYGB and SG, major complications [2.21 vs. 1.7%, p < 0.0001 (RYGB), 1.12 vs. 0.89%, p < 0.0001 (SG)], and mortality [0.23 vs. 0.12%, p < 0.0001 (RYGB), 0.10 vs. 0.05%; p < 0.0001 (SG)]. Conclusion: Males continue to represent a disproportionately small percentage of bariatric surgery patients despite having no difference in obesity rates compared to females. Male gender is an independent risk factor for major post-operative complications and 30-day mortality, even after controlling for comorbidities. [ABSTRACT FROM AUTHOR]

This paper discusses the finite element modeling of cracking of quasi-brittle materials under cyclic loading. A damage based crack model is proposed, which considers tensile and compressive damage, irreversible strains upon unloading in compression, as well as micro-crack closure-reopening effects with special attention to the sliding of open cracks (MCRS). The model is implemented in conjunction with a mixed strain/displacement finite element formulation which provides enhanced accuracy and guarantees mesh size and bias independent results. Two distinct damage models are developed. The first one is based on the classical fixed orthotropic crack models and the second is an isotropic version. Both of them incorporate the necessary elements to furnish full MCRS capabilities. The model is demonstrated through several examples of application and comparison with experimental evidence, in mode I, mode II and mixed mode monotonic and cyclic loading. [ABSTRACT FROM AUTHOR]

Risk assessment and management is an important step towards resilient and sustainable cities. Among many other perils, both natural and manmade, seismic risk is a major threat for resilience and sustainability. In recent decades, several methods for seismic risk assessment have been proposed, including the well-known Vulnerability Index Method (VIM). In this study, a probabilistic version of the VIM, which we call the Vulnerability Index Method-Probabilistic (VIM_P), is proposed. The VIM_P requires essential information on the seismic hazard and on the vulnerability of the building stock. Seismic hazard is determined using the exceedance rates of macroseismic intensities, as defined in the European Macroseismic Scale (EMS). Seismic vulnerability is defined by means of vulnerability probability density functions (pdf) that describe the probability distribution of the corresponding vulnerability index. Beta-like functions are used for these pdfs. VIM_P quantifies seismic vulnerability by means of three vulnerability curves, Lower, Best and Upper, according to the quantity and quality of available information, thus allowing three estimates of seismic vulnerability and risk. Then, seismic risk is computed via the convolution of seismic hazard and seismic vulnerability, considering semi-empirical damage functions. Seismic risk is given through the exceedance frequencies of the damage grades. To highlight the capabilities of the VIM_P, the seismic risk of about 70,000 residential buildings in Barcelona was assessed. According to the results, the exceedance frequency of the collapse damage state for more than the 50% of the buildings in the Eixample district would be greater than 1 × 10−5. This confirms the relatively high seismic risk in the city, mainly due to the high vulnerability of the built environment. Specific software, USERISK20015, has been developed for routine applications of VIM_P. It is hoped that VIM_P and this new tool for seismic risk assessment will be useful to stakeholders and civil protection authorities for risk management and prioritizing actions that can help to create more resilient, sustainable cities. [ABSTRACT FROM AUTHOR]

Among the activities developed under the framework of the Global Earthquake Model, the development of a global consequences database was included. This was defined with the objective of serving as public repository of damages and losses, occurred on different types of elements because of a selected list of earthquakes with epicentres at varying locations around the globe, but also to be used as a benchmark for the development of vulnerability models that capture specific characteristics of the building typologies in each country. The online earthquakes consequences’ database has information on 71 events where 16 of them occurred in the Latin America and the Caribbean Region. A complete and comprehensive review and data gathering process were developed for these selected earthquakes accounting for different aspects and dimensions that were considered of interest, besides the physical damage, such as casualties, socio-economic implications, damages and disruptions in critical facilities and infrastructures, together with the occurrence of secondary events triggered by the ground shaking such as landslides and tsunamis. When possible, the damage and casualties were geo-located using a standardized approach and included in the database. The contributions of the Latin America and Caribbean Region to the database were at the same time a challenge and an opportunity to collect, review, put together and standardize, up to a certain point, damage data of previous earthquakes additionally of being a step forward in the field of open data. [ABSTRACT FROM AUTHOR]

Acute decompensated heart failure (ADHF) is a common reason for admission to the hospital, and readmission is frequent. Multiple factors contribute to rehospitalizations, but inadequate assessment of volume status leading to persistent congestion is an important factor. We sought to determine if focused cardiac ultrasound (FCU) of the inferior vena cava (IVC), as a surrogate of volume status, would predict readmission of ADHF patients after index hospitalization. Patients admitted with a primary diagnosis of ADHF were prospectively enrolled. All patients underwent FCU of the IVC on admission and then daily. 82 patients were enrolled. Patients demonstrated improvement in heart failure physical examination findings and symptoms during the hospitalization. There was a reduction in the size of the IVC and a significant increase in patients with small collapsible vena cava. Logistic regression analysis of physical examination, patient symptoms, and IVC parameters at discharge demonstrated IVC collapsibility and patient reported dyspnea improvement as the only significant variables to predict readmission or emergency department visit. FCU assessment of IVC size and collapsibility may be useful in patients with ADHF to predict risk of being readmitted within 30 days of hospital discharge. [ABSTRACT FROM AUTHOR]

This paper discusses the modeling of cracking in quasi-brittle materials using isotropic and orthotropic damage constitutive laws. A mixed strain/displacement finite element formulation is used, taking advantage of its enhanced precision and its enforced interelemental strain continuity. On the one hand, this formulation avoids the spurious mesh dependency of the computed solution associated to standard elements and does not require the use of tracking techniques. On the other hand, it greatly alleviates the spurious stress locking associated to the use of orthotropic models on standard finite elements. The performance of several isotropic and orthotropic damage constitutive laws is assessed through an extensive comparison with analytical solutions, numerical tests and experimental evidence reported in the literature. The behavior of the different damage models in terms of crack surface, collapse mechanism and force displacement curves is investigated performing 3D analyses in several conditions including Mode I, Mixed Mode and Mode III fracture. When performing the appraisement of planar, bending and twisting cracks, the enhanced accuracy of the mixed formulation allows for a distinct assessment of the several damage models considered. Aspects related to the behavior of damage models, such as the influence of Poisson’s ratio, the shape of the damage surface and the adoption of isotropic and orthotropic models are investigated and noteworthy conclusions are drawn. [ABSTRACT FROM AUTHOR]

Recently proposed capacity-based damage indices and parametric models for capacity curves are applied to frame steel buildings located in soft soils of the Mexico City. To do that, the seismic performance of 2D models of low-, mid- and high-rise buildings is assessed. Deterministic and probabilistic nonlinear static and incremental dynamic analyses are implemented. Monte Carlo simulations and the Latin Hypercube sampling technique are used. Seismic actions are selected among accelerograms recorded in the study area. Spectral matching techniques are applied, so that the acceleration time histories have a predefined mean response spectrum and controlled error. The design spectrum of the Mexican seismic code for the zone is used as target spectrum. The well-known Park and Ang damage index allows calibrating the capacity-based damage index. Both damage indices take into account the contribution to damage of the stiffness degradation and of the energy dissipation. Damage states and fragility curves are also obtained and discussed in detail. The results reveal the versatility, robustness and reliability of the parametric model for capacity curves, which allow modelling the nonlinear part of the capacity curves by the cumulative integral of a cumulative lognormal function. However, these new capacity-based damage index and capacity models have been tested for and applied to 2D frame buildings only; they have not been applied to 3D building models yet. The Park and Ang and the capacity-based damage indices show that for the analysed buildings, the contribution to damage of the stiffness degradation is in the range 66–77% and that of energy loss is in the range 29–34%. The lowest contribution of energy dissipation (29%) is found for the low-rise, more rigid, building. The energy contribution would raise with the ductility of the building and with the duration of the strong ground motion. High-rise frame buildings in soft soils of Mexico City show the worst performance so that the use of adequate braced frames to control the displacements could be recommended. [ABSTRACT FROM AUTHOR]

This paper discusses the finite element modeling of cracking in quasi-brittle materials. The problem is addressed via a mixed strain/displacement finite element formulation and an isotropic damage constitutive model. The proposed mixed formulation is fully general and is applied in 2D and 3D. Also, it is independent of the specific finite element discretization considered; it can be equally used with triangles/tetrahedra, quadrilaterals/hexahedra and prisms. The feasibility and accuracy of the method is assessed through extensive comparison with experimental evidence. The correlation with the experimental tests shows the capacity of the mixed formulation to reproduce the experimental crack path and the force-displacement curves with remarkable accuracy. Both 2D and 3D examples produce results consistent with the documented data. Aspects related to the discrete solution, such as convergence regarding mesh resolution and mesh bias, as well as other related to the physical model, like structural size effect and the influence of Poisson's ratio, are also investigated. The enhanced accuracy of the computed strain field leads to accurate results in terms of crack paths, failure mechanisms and force displacement curves. Spurious mesh dependency suffered by both continuous and discontinuous irreducible formulations is avoided by the mixed FE, without the need of auxiliary tracking techniques or other computational schemes that alter the continuum mechanical problem. [ABSTRACT FROM AUTHOR]

In this work, the vulnerability of an unreinforced masonry building, evaluated on the one hand by using the incremental dynamic analysis, and on the other hand by using nine representative non-linear static incremental procedures, is compared. For comparison reasons among the different non-linear static procedures, the obtained incremental dynamic analyses results are used as reference values. The aim of this analysis is to evaluate the applicability and reliability of the diverse non-linear static procedures for unreinforced masonry buildings, and to propose modifications oriented to improve their use in this typology of structures. For this purpose, a fully representative unreinforced masonry building of the dominating building type in the Eixample district of Barcelona, is analyzed. Furthermore, the conditional spectrum approach procedure has been applied with the aim to conveniently define the seismic demand. Regarding the definition of the fragility curves, two different methodologies were used for each non-linear static procedure and incremental dynamic analyzes. Subsequently, the corresponding damage indices as well as the damage curves were calculated and compared for the different considered peak ground acceleration values. The results of this comparison seem to confirm that the damage curves obtained by performing the NSP and by applying the Risk-UE methodology overestimate the damage corresponding to low values of the PGA and underestimate the damage for higher values of the PGA. [ABSTRACT FROM AUTHOR]

The probabilistic seismic hazard analysis for Romania is revisited within the framework of the BIGSEES national research project () financed by the Romanian Ministry of Education and Scientific Research in the period 2012-2016. The scope of this project is to provide a refined description of the seismic action for Romanian sites according to the requirements of Eurocode 8. To this aim, the seismicity of all the sources influencing the Romanian territory is updated based on new data acquired in recent years. The ground-motion models used in the analysis, as well as their corresponding weights, are selected based on the results from several recent papers also published within the framework of the BIGSEES project. The seismic hazard analysis for Romania performed in this study are based on the traditional Cornell-McGuire approach. Finally, the results are discussed and compared with the values obtained in the recently completed SHARE research project. The BIGSEES and SHARE results are not directly comparable since the considered soil conditions are different-actual soil classes for BIGSEES and rock for SHARE. Nevertheless, the analyses of the seismic hazard results for 200 sites in Romania reveal considerable differences between the seismic hazard levels obtained in the present study and the SHARE results and point out the need for further analyses and thorough discussions related to the two seismic hazard models, especially in the light of a possible future harmonized hazard map for Europe. [ABSTRACT FROM AUTHOR]

Medellín is the second largest city of Colombia with more than 2 million inhabitants according to the latest census and with more than 240,000 public and private buildings. It is located on an intermediate seismic hazard area according to the seismic zonation of Colombia although no destructive earthquakes have occurred having as a consequence low seismic risk awareness among its inhabitants. Using the results of a fully probabilistic risk assessment of the city with a building by building resolution level and considering the dynamic soil response, average annual losses by sectors as well as casualties and other direct effects are obtained and aggregated at county level. Using the holistic evaluation module of the multi-hazard risk assessment CAPRA platform, EvHo, a comprehensive assessment that considered the social fragility and lack or resilience at county level is performed making use of a set of indicators with the objective of capturing the aggravating conditions of the initial physical impact. The urban seismic risk index, USRi, is obtained at county level which is useful to communicate risk to decision-makers and stakeholders besides making easy identifying potential zones that can be problematic in terms of several dimensions of the vulnerability. This case study is an example of how a multidisciplinary research on disaster risk reduction helps to show how risk analysis can be of high relevance for decision-making processes in disaster risk management. [ABSTRACT FROM AUTHOR]

A parametric model for capacity curves and capacity spectra is proposed. The capacity curve is considered to be composed of a linear part and a nonlinear part. The normalized nonlinear part is modelled by means of a cumulative lognormal function. Instead, the cumulative Beta function can be used. Moreover, this new conceptualization of the capacity curves allows defining stiffness and energy functions relative to the total energy loss and stiffness degradation at the ultimate capacity point. Based on these functions, a new damage index is proposed and it is shown that this index, obtained from nonlinear static analysis, is compatible with the Park and Ang index obtained from dynamic analysis. This capacity based damage index allows setting up a fragility model. Specific reinforced concrete buildings are used to illustrate the adequacy of the capacity, damage and fragility models. The usefulness of the models here proposed is highlighted showing how the parametric model is representative for a family of capacity curves having the same normalized nonlinear part and how important variables can be tabulated as empirical functions of the two main parameters defining the capacity model. The availability of this new mathematical model may be a powerful tool for current earthquake engineering research, especially in seismic risk assessments at regional scale and in probabilistic approaches where massive computations are needed. [ABSTRACT FROM AUTHOR]

Understanding and evaluating disaster risk due to natural hazard events such as earthquakes creates powerful incentives for countries to develop planning options and tools to reduce potential damages. The use of models for earthquake risk evaluation allows obtaining outputs such as the loss exceedance curve, the expected annual loss and the probable maximum loss, which are probabilistic metrics useful for risk analyses, for designing strategies for risk reduction and mitigation, for emergency response strategies and for risk financing. This article presents, based on probabilistic risk models, the design and implementation of a risk transfer instrument to cover the private buildings of the city of Manizales, Colombia. This voluntary collective instrument provides financial protection to both, the estate tax payers and the low-income homeowners through a cross-subsidy strategy; besides, it promotes not only the insurance culture but also the solidarity of the community. The city administration and the insurance industry are promoting this program using the mechanism of the property tax payment. This collective insurance helps the government to access key resources for low-income householders recovery and improve disaster risk management at local level. [ABSTRACT FROM AUTHOR]

Taken into account that the natural hazard risk is a contingent liability and, therefore, a sovereign risk for national governments, it is important to assess properly the potential losses to design a suitable risk reduction, retention and transfer strategy. In this article, a disaster risk assessment methodology is proposed based on two approaches: on the one hand, the empiric estimation of losses, using information available from local disaster databases, allowing estimating losses due to small-scale events and, on the other hand, probabilistic evaluations to estimate losses for greater or even catastrophic events, for which information usually is not available due to the lack of historical data. A 'hybrid' loss exceedance curve is thus determined, which combines the results of these two approaches and represents the disaster risk in a proper and complete way. This curve merges two components: the corresponding to small and moderate losses, calculated using an inductive and retrospective analysis, and the corresponding to extreme losses, calculated using a deductive and prospective analysis. Applications of this risk assessment technique are given in this article for eleven countries. [ABSTRACT FROM AUTHOR]

The main goals of this article are to analyze the use of simplified deterministic nonlinear static procedures for assessing the seismic response of buildings and to evaluate the influence that the uncertainties in the mechanical properties of the materials and in the features of the seismic actions have in the uncertainties of the structural response. A reinforced concrete building is used as a guiding case study. In the calculation of the expected spectral displacement, deterministic nonlinear static methods are simple and straightforward. For not severe earthquakes these approaches lead to somewhat conservative but adequate results when compared to more sophisticated procedures involving nonlinear dynamic analyses. Concerning the probabilistic assessment, the strength properties of the materials, concrete and steel, and the seismic action are considered as random variables. The Monte Carlo method is then used to analyze the structural response of the building. The obtained results show that significant uncertainties are expected; uncertainties in the structural response increase with the severity of the seismic actions. The major influence in the randomness of the structural response comes from the randomness of the seismic action. A useful example for selected earthquake scenarios is used to illustrate the applicability of the probabilistic approach for assessing expected damage and risk. An important conclusion of this work is the need of broaching the fragility of the buildings and expected damage assessment issues from a probabilistic perspective. [ABSTRACT FROM AUTHOR]

The risk evaluation model CAPRA (Comprehensive Approach to Probabilistic Risk Assessment) is a techno-scientific methodology and information platform, composed of tools for evaluating and communicating risk at various territorial levels. The model allows evaluating losses on exposed elements using probabilistic metrics, such as the loss exceedance curve, the expected annual loss and the probable maximum loss, useful for multi-hazard risk analyses. In this article, the process of probabilistic seismic risk analysis is described, explaining the main features of the CAPRA modules of hazard, vulnerability and risk estimation applied to the city of Barcelona, Spain. In addition, according to the physical risk results and the information on the socioeconomic indicators of the city, this article presents the holistic evaluation of seismic risk, which is a valuable result to facilitate the integrated risk management by the different stakeholders involved in risk reduction decision making. [ABSTRACT FROM AUTHOR]

This article presents a methodology for an estimate of the benefit cost ratio of the seismic risk reduction in buildings portfolio at broadscale, for a world region, allowing comparing the results obtained for the countries belonging to that region. This methodology encompasses (1) the generation of a set of random seismic events and the evaluation of the spectral accelerations at the buildings location; (2) the estimation of the buildings built area, the economic value, as well as the classification in structural typologies; (3) the development of vulnerability curves for each typology; (4) the estimation of the annual average loss of the buildings portfolio in the current conditions as well as in the case of a hypothetical structural intervention. The benefit cost ratio is estimated as the difference between the estimates of the present value of these two annual average losses, divided by the retrofitting costs. This methodology has been applied to the portfolio of public schools of 14 countries of Latin America and the Caribbean, for evaluating the feasibility of the seismic risk reduction at a national scale. [ABSTRACT FROM AUTHOR]

The paper deals with the development of a general as well as integrative and holistic framework to systematize and assess vulnerability, risk and adaptation. The framework is a thinking tool meant as a heuristic that outlines key factors and different dimensions that need to be addressed when assessing vulnerability in the context of natural hazards and climate change. The approach underlines that the key factors of such a common framework are related to the exposure of a society or system to a hazard or stressor, the susceptibility of the system or community exposed, and its resilience and adaptive capacity. Additionally, it underlines the necessity to consider key factors and multiple thematic dimensions when assessing vulnerability in the context of natural and socio-natural hazards. In this regard, it shows key linkages between the different concepts used within the disaster risk management (DRM) and climate change adaptation (CCA) research. Further, it helps to illustrate the strong relationships between different concepts used in DRM and CCA. The framework is also a tool for communicating complexity and stresses the need for societal change in order to reduce risk and to promote adaptation. With regard to this, the policy relevance of the framework and first results of its application are outlined. Overall, the framework presented enhances the discussion on how to frame and link vulnerability, disaster risk, risk management and adaptation concepts. [ABSTRACT FROM AUTHOR]

DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging. It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair. Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks (DSBs) in yeast. Here, we show that the human nucleoporin 153 (NUP153) has a role in repair of DSBs and in the activation of DNA damage checkpoints. We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to investigate the relationship between protein intake and dynapenia. Design: A cross-sectional/observational study. Setting: Department of Kinanthropology at the University of Quebec at Montreal. Participants: Seventy-two non-frail postmenopausal women aged between 50 to 75 years were recruited. Measurements: Body weight (BW), lean body mass (LBM; %) and skeletal muscle mass (bio-electrical impedancemetry analysis), maximum voluntary handgrip strength (using hand dynamometer), aerobic capacity (VO2peak) and dietary intake were measured. Women were divided according to dynapenia criteria. Results: The strongest correlation between muscle strength and protein intake was observed when we express the amount of protein in g/d/BW. No differences for age, BMI, status of menopause, fat mass and V02peak were observed between non-dynapenic, type I dynapenic and type II dynapenic women, independently of the criteria used. We observed significant differences in protein intake (g/d/BW) between non-dynapenic and type II dynapenic (p<0.01) as well as between type I dynapenic and type II dynapenic (p<0.01) when dynapenia was expressed in kg/BW and in kg/LBM, respectively. It should be noted that no differences in LBM between the three groups were observed when dynapenia was expressed in kg/BW and kg/LBM. Protein intake for all groups respected the RDA of 0.8 to 1.2 g/d/BW (non-dynapenic: 1.44/1.38; type I dynapenic: 1.30/1.33; type II dynapenic: 1.05/1.08 g/d/BW). Conclusions: Protein intake seems to play a role in the development of dynapenia particularly at the level of type II dynapenia. Therefore, an increase in the recommended daily allowance for protein intake may be warranted. [ABSTRACT FROM AUTHOR]

The seismic risk evaluation usually works with a fragmented concept of risk, which depends on the scientific discipline in charge of the assessment. To achieve an effective performance of the risk management, it is necessary to define risk as the potential economic, social and environmental consequences due to a hazardous phenomenon in a period of time. This article presents a methodology which evaluates the seismic risk from a holistic perspective, which means, it takes into account the expected physical damage and also the conditions related to social fragility and lack of resilience, which favour the second order effects when a hazard event strikes an urban centre. This seeks to obtain results which are useful in the decision making process for risk reduction. The proposed method for urban seismic risk evaluation uses the fuzzy sets theory in order to handle qualitative concepts and variables involved in the assessment, the physical risk level and aggravation level, related to the social fragility and the lack of resilience, are evaluated and finally a total risk level is determinate. [ABSTRACT FROM AUTHOR]

Between the late nineteenth century and the early twentieth century, Barcelona was expanded, occupying the terrains connecting the old walled city and the nearby towns of the plateau of Barcelona. At that time, a large number of unreinforced masonry buildings were constructed and nowadays many of them are still used as dwellings. Though built individually, these buildings are connected to adjacent buildings, forming blocks composed of aggregates. In order to analyze the seismic behavior of isolated buildings and aggregates, two typical central buildings and one typical corner building have been chosen. The two central buildings and the corner building are referred as C1, C2, and E buildings. Two corner buildings and two central buildings have been connected in order to simulate a block side. This aggregate is referred as AGG and it is composed by the following sequence of individual buildings: E- C1- C2- E. Original plans and drawings of existing buildings are then used to model these buildings. The modeled buildings have five stories. Standard pushover analyses lead to evaluate their seismic performance by means of capacity spectra and fragility curves. The analysis has been carried out in the parallel (Ux) and transversal (Uy) directions to the street. Then, a capacity spectrum based method is used to analyze the seismic behavior of these buildings considered as individual buildings and as an aggregate. Two earthquake scenarios are considered. The first one is a deterministic scenario which is based on a historical earthquake occurred in 1,824, 25 km away from the city and the second one is a probabilistic scenario, which represents the ground motion with a probability of occurrence of 10% in 50 years. The soil local effects have been also considered and both scenarios have been used to assess the expected damage. Four non-null damage states are considered: slight (1), moderate (2), severe (3) and extensive-to-collapse (4). For the type of soil where most of the buildings are, and in the Ux direction, the four buildings show a similar behavior. The mean damage grade is 2.3 for the deterministic scenario and 2.7 for the probabilistic one. This means that moderate to severe damage is expected in both cases; furthermore, in the case of the deterministic scenario more than 10% of the buildings would suffer extensive-to-collapse damage and nearly 20% for the probabilistic scenario, confirming the high vulnerability of such buildings. The differences in the expected damage are due to the significant different characteristics of the response spectra of the earthquake scenarios in the range of the fundamental periods of the buildings. [ABSTRACT FROM AUTHOR]

Aging is associated with decreases in muscle mass, muscle strength and muscle power, with muscle strength declining at a higher rate than muscle mass, but at a lower rate than muscle power. This progressive mismatch suggests a deterioration of muscle 'quality' that may lead to functional incapacities. Although it may be difficult to synthesize the concept of muscle quality, the aim of the present paper was to propose a clinical definition of muscle quality in regard to the functional status. Accordingly, the muscle strength or muscle power per unit of muscle mass ratios appear to be clinically relevant markers of muscle quality. Several mechanisms susceptible to influence these ratios have been described, among which age, gender, sex hormones, obesity, physical activity and fibrosis. Various methods to assess muscle quality in both the clinical and research fields have also been listed, with a particular interest for the tests used to measure muscle power. Finally, we proposed a clinical screening tool to detect individuals at risk of functional incapacities. Briefly, the muscle quality score is based on handgrip strength assessment by hand dynamometer, muscle mass measurement by bioelectrical analysis, and leg muscle power estimation using a chair stand test. [ABSTRACT FROM AUTHOR]

The Capacity Spectrum Based Method developed in the framework of the European project Risk-UE has been applied to evaluate the seismic risk for the city of Barcelona, Spain. Accordingly, four damage states are defined for the buildings, the action is expressed in terms of spectral values and the seismic quality of the buildings, that is, their vulnerability, is evaluated by means of capacity spectra. The probabilities of the damage states are obtained considering a lognormal probability distribution. The most relevant seismic risk evaluation results obtained for Barcelona, Spain, are given in the article as scenarios of expected losses. [ABSTRACT FROM AUTHOR]