1. Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review.
- Author
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Wang, Duo-Zi, Li, Bing-Hu, Deng, Bin-Lu, Guo, Fu-Qiang, Hu, Shan-Shan, Yu, Neng-Wei, and Liu, Jie
- Subjects
ANTI-NMDA receptor encephalitis ,ENCEPHALITIS ,LITERATURE reviews ,MAGNETIC resonance imaging ,LOSS of consciousness ,NEUROPSYCHOLOGICAL tests - Abstract
It has been assumed that patients with strict immunosuppressive treatment after solid organ transplantation have only marginal risk in developing autoimmune encephalitis. We reported a woman in her late 40 s who presented with generalized convulsions and loss of consciousness. After detailed history review, neuropsychological tests, metagenomic next-generation sequencing of serum and cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) brain, and electroencephalogram, she was diagnosed as anti-CASPR2 encephalitis based on the positive anti-CASPR2 auto-antibody in serum and CSF. The patient underwent liver transplantation and has taken lenvatinib for 2 months, in addition to tacrolimus, mycophenotale mofetil, and entecavir administered for half a year. This case was the first report of anti-CASPR2 encephalitis in post–organ transplantation patients. Together with the reports of other encephalitis cases in organ transplantation, it warns the possibility of developing immune-oriented encephalitis in patients undergoing immunosuppression, especially in combination with other treatments of immunomodulatory activity. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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