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2 results on '"Birch extract"'

1. Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation.

Author

Dehelean, Cristina A., Şoica, Codruţa, Ledeţi, Ionuţ, Aluaş, Mihaela, Zupko, Istvan, Găluşcan, Atena, Cinta-Pinzaru, Simona, and Munteanu, Melania

Subjects
*BETULIN, *TRITERPENES, *BIRCH, *CANCER cells, *SPECTRUM analysis, *SPECTROMETRY
Abstract

Background: Pentacyclic triterpenes, mainly betulin and betulinic acid, are valuable anticancer agents found in the bark of birch tree. This study evaluates birch bark extracts for the active principles composition. Results: New improved extraction methods were applied on the bark of Betula pendula in order to reach the maximum content in active principles. Extracts were analyzed by HPLC-MS, Raman, SERS and 13C NMR spectroscopy which revealed a very high yield of betulin (over 90%). Growth inhibiting effects were measured in vitro on four malignant human cell lines: A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), HeLa (cervix adenocarcinoma) and MCF7 (breast adenocarcinoma), by means of MTT assay. All of the prepared bark extracts exerted a pronounced antiproliferative effect against human cancer cell lines. In vivo studies involved the anti-inflammatory effect of birch extracts on TPA-induced model of inflammation in mice. Conclusions: The research revealed the efficacy of the extraction procedures as well as the antiproliferative and anti-inflammatory effects of birch extracts. [ABSTRACT FROM AUTHOR]

Published
2012
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2. Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

Author

Codruţa Şoica, Cristina Dehelean, Atena Gǎluşcan, Mihaela Aluas, Simona Cinta-Pinzaru, István Zupkó, Melania Munteanu, and Ionuţ Ledeţi

Subjects
Chemistry(all), Breast Adenocarcinoma, Birch extract, HeLa, chemistry.chemical_compound, In vivo, Betulinic acid, MTT assay, 13C NMR, QD1-999, Raman, Betulin, Traditional medicine, biology, SERS, General Chemistry, biology.organism_classification, Chemistry, Anticancer, chemistry, Epidermoid carcinoma, visual_art, visual_art.visual_art_medium, Bark, Research Article
Abstract

Background Pentacyclic triterpenes, mainly betulin and betulinic acid, are valuable anticancer agents found in the bark of birch tree. This study evaluates birch bark extracts for the active principles composition. Results New improved extraction methods were applied on the bark of Betula pendula in order to reach the maximum content in active principles. Extracts were analyzed by HPLC-MS, Raman, SERS and 13C NMR spectroscopy which revealed a very high yield of betulin (over 90%). Growth inhibiting effects were measured in vitro on four malignant human cell lines: A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), HeLa (cervix adenocarcinoma) and MCF7 (breast adenocarcinoma), by means of MTT assay. All of the prepared bark extracts exerted a pronounced antiproliferative effect against human cancer cell lines. In vivo studies involved the anti-inflammatory effect of birch extracts on TPA-induced model of inflammation in mice. Conclusions The research revealed the efficacy of the extraction procedures as well as the antiproliferative and anti-inflammatory effects of birch extracts.

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