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Southern Africa is particularly sensitive to climate change, due to both ecological and socio-economic factors, with rural land users among the most vulnerable groups. The provision of information to support climate-relevant decision-making requires an understanding of the projected impacts of change and complex feedbacks within the local ecosystems, as well as local demands on ecosystem services. In this paper, we address the limitation of current approaches for developing management relevant socio-ecological information on the projected impacts of climate change and human activities. We emphasise the need for linking disciplines and approaches by expounding the methodology followed in our two consecutive projects. These projects combine disciplines and levels of measurements from the leaf level (ecophysiology) to the local landscape level (flux measurements) and from the local household level (socio-economic surveys) to the regional level (remote sensing), feeding into a variety of models at multiple scales. Interdisciplinary, multi-scaled, and integrated socio-ecological approaches, as proposed here, are needed to compliment reductionist and linear, scale-specific approaches. Decision support systems are used to integrate and communicate the data and models to the local decision-makers. [ABSTRACT FROM AUTHOR]

The article presents as study whose aim was to determine the neurological and ophthalmological manifestations of SPG4-related hereditary spastic paraplegias (HSP) and he overall neurological disability including cognitive function was also assessed. As stated, the examinations were carried out on ten patients from the North of England who had been confirmed for pathogenic SPG4 mutations. The article further discusses the results of the study in terms of ophthalmological complications.

A correction to the article "The neurological and ophthalmological manifestations of SPG4-related hereditary spastic paraplegia" that was published in the 2 February 2016 issue is presented.