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Tropical Cyclone (TC) formation regions are analysed in twelve CMIP5 models using a recently developed diagnostic that provides a model-performance summary in a single image for the mid-summer TC season. A subjective assessment provides an indication of how well the models perform in each TC basin throughout the globe, and which basins can be used to determine possible changes in TC formation regions in a warmer climate. The analysis is necessarily succinct so that seven basins in twelve models can be examined. Consequently, basin performance was reduced to an assessment of two common problems specific to each basin. Basins that were not too adversely affected were included in the projection exercise. The North Indian basin was excluded because the mid-summer analysis period covers a lull in TC activity. Surprisingly, the North Atlantic basin also had to be excluded, because all twelve models failed the performance assessment. A slight poleward expansion in the western North Pacific and an expansion towards the Hawaiian Islands in the eastern North Pacific is plausible in the future, while a contraction in the TC formation regions in the eastern South Indian and western South Pacific basins would reduce the Australian region TC formation area. More than half the models were too active in the eastern South Pacific and South Atlantic basins. However, projections based on the remaining models suggest these basins will remain hostile for TC formation in the future. These southern hemisphere changes are consistent with existing projections of fewer southern hemisphere TCs in a future warming world [ABSTRACT FROM AUTHOR]

5-Methoxypsoralen (5 MOP) administred daily (40 mg at 9 p.m.) was compared with placebo in the treatment of severe depression. The clinical response was evaluated using the Hamilton Depression Rating Scale after 1 week of treatment. Our preliminary data indicate that patients receiving 5 MOP improved significantly after 1 week, whereas patients treated with placebo did not. The stimulating effect of 5 MOP on the melatonin secretion may be involved in this clinical effect. [ABSTRACT FROM AUTHOR]