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Abstract Background  The optimal blood pressure (BP) for treating acute intracerebral hemorrhage remains (ICH) uncertain. High BP may contribute to hematoma growth while excessive BP reduction might precipitate peri-hemorrhage ischemia. We examine here the feasibility and safety of reducing BP to lower than presently recommended levels in patients with acute ICH. Methods  Patients with ICH were prospectively randomized to standard BP treatment (mean arterial BP [MAP] 110–130 mmHg) or aggressive BP lowering (MAP  Results  We enrolled 21 patients into each group. Mean age was 60.6 ± 12.3 years and MAP on presentation was 147.6 ± 18.2 mmHg. Treatment was started on average 3.2 ± 2.2 h after symptom onset. Baseline clinical variables were identical between the 2 treatment groups. Target blood pressure was achieved within 87.1 ± 59.6 min in the standard group and 163.5 ± 163.8 min in the aggressive BP treatment group. There were no significant differences in early neurological deterioration, hematoma and edema growth, and clinical outcome at 90 days. Conclusion  A more aggressive reduction of acute hypertension after ICH does not increase the rate of neurological deterioration even when treatment is initiated within hours of symptom onset. Lowering BP aggressively did not affect hematoma and edema expansion but this possibility deserves further study. [ABSTRACT FROM AUTHOR]