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Backgroud: The efficacy and safety of self-expandable metallic stents (SEMSs) as a bridge for patients with acute malignant colorectal obstructions (AMCOs) are still controversial. We conducted this study to evaluate the outcomes of patients with AMCOs treated by different strategies. Methods: From January 2010 to March 2014, a total of 171 patients with AMCOs from Zhongshan Hospital were retrospectively enrolled in this study. One hundred twenty patients successfully received stent placement followed by one-stage laparoscopic or open resection in the stent group, and 51 patients received emergency operations in the emergency group. Results: The operation duration and postoperative hospital stay were significantly shorter in the stent group (114.51 ± 28.65 vs. 160.39 ± 58.94 min, P < 0.001; 8.00 ± 3.97 vs. 12.59 ± 9.07 days, P = 0.001). The stent group also had significantly reduced intraoperative blood loss and the incidence of postoperative complications compared with the emergency group (61.00 ± 43.70 vs. 121.18 ± 85.90 ml, P < 0.001; 16.7 vs. 37.3 %, P = 0.003). Kaplan-Meier survival curves showed that the median survival time in the stent group was significantly longer than that in the emergency group (53 vs. 41 months, P = 0.034). In subgroup analysis of stent group, the stent laparoscopy group had significantly decreased postoperative complications ( P = 0.025), and similar long-term survival ( P = 0.81). Conclusions: Stent placement as a bridge to surgery is a safe and feasible procedure and provides significant advantages in terms of short-term outcomes and favorable prognoses for patients with AMCOs. Laparoscopic surgery could be considered as an optimal treatment after stent placement. [ABSTRACT FROM AUTHOR]

A new rumenic acid derivative, threo-9,10-O-isopropylidene-13-hydroxy-(11E)-octadecenoic acid ( 1), and two known compounds, steppogenin ( 2) and oxyresveratrol ( 3), were isolated from the roots of Cudrania tricuspidata. The structure of the new compound was established by spectroscopic methods. All the compounds were evaluated for their cytotoxicity against three human tumor cell lines (HepG2, HCT-116, and SGC-7901). Unfortunately, none of them exhibited significant cytotoxicity at a concentration of 100 μM. [ABSTRACT FROM AUTHOR]