1. The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study
- Author
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Dawn Kleindorfer, Kathleen Alwell, Samir Belagaje, Sepideh F. Varon, Opeolu Adeoye, Patrick Gillard, Charles J Moomaw, Daniel Woo, Matthew L. Flaherty, Simona Ferioli, Brett M. Kissela, Pooja Khatri, and Heidi Sucharew
- Subjects
Male ,medicine.medical_specialty ,Comorbidity ,Cohort Studies ,Disability Evaluation ,Quality of life ,medicine ,Humans ,Longitudinal Studies ,Survivors ,Spasticity ,Longitudinal cohort ,Stroke survivor ,Stroke ,stroke rehabilitation ,Aged ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,spasticity ,General Medicine ,Middle Aged ,medicine.disease ,humanities ,3. Good health ,Patient Outcome Assessment ,Clinical trial ,quality of life ,Muscle Spasticity ,Physical therapy ,Female ,medicine.symptom ,business ,Follow-Up Studies ,Cohort study - Abstract
Background Spasticity often leads to symptomatic and functional problems that can cause disability for stroke survivors. We studied whether spasticity has a negative impact on health-related quality of life (HRQoL). Methods As part of the Greater Cincinnati/Northern Kentucky Stroke Study (NCT00642213), 460 ischemic stroke patients were interviewed during hospitalization and then followed over time. HRQoL was measured by the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the Short Form-12 (SF-12), EuroQol-5 dimension (EQ-5D), and Stroke-Specific Quality of Life (SSQOL) instruments, with lower scores indicating worse health. HRQoL differences between stroke survivors with and without spasticity were compared, adjusting for age, race, stroke severity, pre-stroke function, and comorbidities. Results Of the 460 ischemic stroke patients, 328 had spasticity data available 3 months after their stroke (mean age of 66 years, 49 % were female, and 26 % were black). Of these patients, 54 (16 %) reported having spasticity. Three months following their stroke, patients who reported spasticity had lower mean scores on the PCS (29.6 ± 1.4 vs 37.3 ± 0.6; P
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