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Breast cancer is a devastating malignancy, among which the luminal A (LumA) breast cancer is the most common subtype. In the present study, we used a comprehensive bioinformatics approach in the hope of identifying novel prognostic biomarkers for LumA breast cancer patients. Transcriptomic profiling of 611 LumA breast cancer patients was downloaded from TCGA database. Differentially expressed genes (DEGs) between tumor samples and controls were first identified by differential expression analysis, before being used for the weighted gene co-expression network analysis. The subsequent univariate Cox regression and LASSO algorithm were used to uncover key prognostic genes for constructing multivariate Cox regression model. Patients were stratified into high-risk and low-risk groups according to the risk score, and subjected to multiple downstream analyses including survival analysis, gene set enrichment analysis (GSEA), inference on immune cell infiltration and analysis of mutation burden. Receiving operator curve analysis was also performed. A total of 7071 DEGs were first identified by edgeR package, pink module was found significantly associated with invasive lobular carcinoma (ILC). 105 prognostic genes and 9 predictors were identified, allowing the identification of a 5-key prognostic genes (LRRC77P, CA3, BAMBI, CABP1, ATP8A2) after intersection. These 5 genes, and the resulting Cox model, displayed good prognostic performance. Furthermore, distinct differences existed between two risk-score stratified groups at various levels. The identified 5-gene prognostic model will help deepen the understanding of the molecular and immunological mechanisms that affect the survival of LumA-ILC patients and guide and proper monitoring of these patients. [ABSTRACT FROM AUTHOR]

We theoretically and numerically prove that under an electromagnetic plane wave with linear polarization incident normally to a single nanowire, there exists a power diagram that could indicate scattering properties for any system configurations, material parameters, and operating wavelength. We demonstrate the distinct power distribution boundary in absorption, scattering, and extinction for a generalized nanowire with any partial wave modes dominant. In the boundary, each dominant scattering coefficients remain constant, and its energy performance would display superabsorbers or superscatterers. Interestingly, for a system with larger partial wave modes dominant, the occupied domain in the power diagram could completely cover that with lower ones. Hence, a system with different levels of partial wave modes can display the same power results, reflecting the degeneracy. This degenerate property could release more degrees of freedom in design of energy harvesting devices and sensors. We demonstrate several systems based on realistic materials to support our findings. [ABSTRACT FROM AUTHOR]

Estimating distance of objects relative to one's body is important for interaction with the environment. Given that distance is an interval of magnitude describing space, distance and the commonly used estimations of magnitude, i.e., numbers, may share a common representation system (the ATOM theory, Walsh in Trends Cogn Sci 7(11):483-488, ). The current study systematically examined the association between distance and number representations on both the sagittal and transverse axes on the transverse plane in the peripersonal space. Participants in Experiment 1 judged the parity of digits by pressing one of two buttons (both were in front of participants): One was near the body and the other away from it. We found that near responses were faster when paired with smaller numbers and far responses with larger numbers. When one button was set in front and the other in back in Experiment 2, no mapping was found. In Experiment 3, when both buttons were on the right side aligned with the transverse axis, small-near and large-far mapping were found. However, no such effect was found on the left side. These results suggest that numbers are mapped onto the whole transverse plane of the peripersonal space, not only a left-right oriented number line. [ABSTRACT FROM AUTHOR]

The 2-D transition metal dichalcogenide (TMD) semiconductors, has received great attention due to its excellent optical and electronic properties and potential applications in field-effect transistors, light emitting and sensing devices. Recently surface plasmon enhanced photoluminescence (PL) of the weak 2-D TMD atomic layers was developed to realize the potential optoelectronic devices. However, we noticed that the enhancement would not increase monotonically with increasing of metal plasmonic objects and the emission drop after the certain coverage. This study presents the optimized PL enhancement of a monolayer MoS2 in the presence of gold (Au) nanorods. A localized surface plasmon wave of Au nanorods that generated around the monolayer MoS2 can provide resonance wavelength overlapping with that of the MoS2 gain spectrum. These spatial and spectral overlapping between the localized surface plasmon polariton waves and that from MoS2 emission drastically enhanced the light emission from the MoS2 monolayer. We gave a simple model and physical interpretations to explain the phenomena. The plasmonic Au nanostructures approach provides a valuable avenue to enhancing the emitting efficiency of the 2-D nano-materials and their devices for the future optoelectronic devices and systems. [ABSTRACT FROM AUTHOR]