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Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5–10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. [ABSTRACT FROM AUTHOR]

The synthesis of bismuth based materials with porous structures for supercapacitor application has drawn much attention due to their high specific surface area and easy access of electrolytes with the electrode surface through their hierarchical pores. In this present report, we synthesized a three dimensional (3D) BiOCOOH micro flowers by a solvothermal approach and applied to supercapacitor applications. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy results confirmed that the formation of porous BiOCOOH flowers. When BiOCOOH was used as electrode material for supercapacitors it exhibits a maximum specific capacitance value of 312 F g−1 at current density of 1 Ag−1. Additionally, the BiOCOOH flowers retained 52% of its initial specific capacity after 5000 charge–discharge cycles indicating an excellent cyclic stability. This improvement in the cycle stability of the BiOCOOH is ascribed to high surface area and enhanced ion transport through the pores of the BiOCOOH flowers. This high specific capacitance and excellent cyclic stability of the porous BiOCOOH flowers prove to be a promising candidate for supercapacitor application. [ABSTRACT FROM AUTHOR]

The tribological behavior of Babbitt alloy rubbing with SiN ball and steel ball with various sliding speeds at dry friction condition was investigated. It was found that B88 alloy rubbing with SiN ball and steel ball possesses a low sliding wear resistance at dry friction. The wear rate is above 10 mm/Nm, and the friction coefficient is from 0.2 to 0.4. At low sliding speed of 0.05-0.1 m/s, the mainly wear mechanisms are microgroove and fatigue wear, while at high sliding speed of 0.5 m/s, the wear mechanisms depend on plastic deformation and delamination. The high wear rate indicates that it is needed to prevent Babbitt alloy from working at dry friction conditions, while the low friction coefficient suggests that it is not easy to the occurrence of cold weld. [ABSTRACT FROM AUTHOR]

Sulphate-functionalized multi-walled carbon nanotubes (S-CNTs) were synthesized by an efficient and convenient method and characterized by FT-IR and TEM methods. Catalytic activities of the S-CNTs were evaluated in the esterification of glycerol with acetic acid at low temperature under atmospheric pressure. The CNTs grafted with sulphate groups show activity and stability in this reaction. The catalyst can be recycled and reused for several times without any significant loss of its catalytic activity. [ABSTRACT FROM AUTHOR]

pure anatase phase nano-SO /TiO catalysts were synthesized and their catalytic activities were tested. Nano-SO/TiO shows high activity and effective re-usable when used as basic catalysts for the synthesis of dioctyl sebacate. [ABSTRACT FROM AUTHOR]