1. PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients.
- Author
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Serretta, V., Catanese, A., Daricello, G., Liotta, R., Allegro, R., Martorana, A., Aragona, F., and Melloni, D.
- Subjects
CANCER patients ,PROSTATE-specific antigen ,BIOPSY ,CLINICAL pathology ,CIPROFLOXACIN - Abstract
Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.Prostate Cancer and Prostatic Diseases (2008) 11, 148–152; doi:10.1038/sj.pcan.4500996; published online 17 July 2007 [ABSTRACT FROM AUTHOR]
- Published
- 2008
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