1. Traveling Wave Solutions in a Model for Tumor Invasion with the Acid-Mediation Hypothesis.
- Author
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Davis, Paige N., van Heijster, Peter, Marangell, Robert, and Rodrigo, Marianito R.
- Subjects
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SINGULAR perturbations , *HYPOTHESIS , *PERTURBATION theory , *TUMORS - Abstract
In this manuscript, we prove the existence of slow and fast traveling wave solutions in the original Gatenby–Gawlinski model. We prove the existence of a slow traveling wave solution with an interstitial gap. This interstitial gap has previously been observed experimentally, and here we derive its origin from a mathematical perspective. We give a geometric interpretation of the formal asymptotic analysis of the interstitial gap and show that it is determined by the distance between a layer transition of the tumor and a dynamical transcritical bifurcation of two components of the critical manifold. This distance depends, in a nonlinear fashion, on the destructive influence of the acid and the rate at which the acid is being pumped. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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