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The corresponding arylamino derivatives were obtained by direct SNH arylamination of 5(6,7)-nitroquinoline N-oxides in anhydrous DMSO. 8-Nitroquinoline N-oxide underwent degradation under these conditions. [ABSTRACT FROM AUTHOR]

Direct SNH amidation of 6- and 7-nitroquinoline N-oxides in anhydrous DMSO allowed to obtain N-oxides of 2- and 8-aroylaminonitroquinolines, respectively. 5-Nitroquinoline N-oxide was transformed into a mixture of amides derived from the N-oxides of 5-nitroand 5-nitrosoquinolines. 8-Nitroquinoline N-oxide underwent destruction under the same conditions. [ABSTRACT FROM AUTHOR]

Arylamino derivatives of both the corresponding nitroquinolones and nitrosoquinolones were first obtained by direct nucleophilic substitution of hydrogen in the molecules of 1-methyl-5(6,7,8)-nitroquinolin-2(1Н)-ones. [ABSTRACT FROM AUTHOR]

SNH Arylamination of 5-, 6-, 7-, and 8-nitroquinolines in anhydrous DMSO gave not only the arylamino derivatives of the respective nitroquinolines, but also the arylamino derivatives of nitrosoquinolines. In the case of 6-nitroquinoline, the first representatives of polycyclic structures on the basis of pyrido[3,2-a]phenazine 7-oxide were isolated. [ABSTRACT FROM AUTHOR]

Goals of work The use of complementary and alternative medicine (CAM) amongst oncology patients is widespread. There is little data regarding the sources of clinical information on CAM that oncology practitioners utilise. The aim of this study was to investigate the sources of clinical information on CAM utilised by Australian oncology practitioners. Methods A structured self-administered questionnaire was sent to Australian oncology practitioners, defined as oncologists, oncology pharmacists and pharmacists at drug information centres (DICs). Key information was sought on their level of satisfaction with the accessibility, reliability and usefulness of this information and the frequency of, and initiating factors for, seeking this information. Main results A substantial proportion of oncologists (57.1%) reported having never sought information on CAM, compared to 27.3% of oncology pharmacists, and 18.8% of DIC pharmacists. Oncologists most commonly reported seeking information on CAM one to three times per year compared to four to ten times per year for oncology pharmacists. Databases were the most common information source used by oncologists (48.1%) and oncology pharmacists (91.7%) and the second most common information source used by DICs (92.3%). There was wide variation in the source of clinical information on CAM used by the three different professional groups. Conclusion Oncology practitioners often seek information on CAM; however the frequency, nature and sources of information utilised varied widely. The usefulness and reliability of the sources utilised were inconsistent. [ABSTRACT FROM AUTHOR]