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Your search keyword '"Dion, J. -L."' showing total 4 results
Start Over Author "Dion, J. -L." Publisher springer nature
4 results on '"Dion, J. -L."'

4. Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders.

Author

Avery, Thomas D., Li, Jiahe, Turner, Dion J. L., Rasheed, Mohd S. U., Cherry, Fisher R., Stachura, Damian L., Rivera-Escalera, Fátima, Ruiz, David M., Lacagnina, Michael J., Gaffney, Caitlyn M., Aguilar, Clarissa, Yu, Jingxian, Wang, Yang, Xie, Huan, Liang, Dong, Shepherd, Andrew J., Abell, Andrew D., and Grace, Peter M.

Subjects
*OXIDATIVE stress, *CHRONIC pain, *NUCLEAR factor E2 related factor, *PROTHROMBIN, *THERAPEUTICS
Abstract

Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) is limited by systemic side effects. We chemically functionalize the NRF2 activator monomethyl fumarate to require Baeyer–Villiger oxidation for release of the active drug at sites of oxidative stress. This prodrug reverses chronic pain in mice with reduced side effects and could be applied to other disorders of oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2024
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