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Background: Black individuals with type 2 diabetes suffer disproportionate morbidity and mortality relative to whites with type 2 diabetes, irrespective of health insurance coverage. Objective: Examine the impact of a primary care–embedded clinical pharmacist–led intervention (UCMyRx) on cardiovascular risk factor control among blacks with type 2 diabetes in a large healthcare system. Design: We used data extracted from the electronic health records (EHR) system and a difference-in-differences study design with a propensity-matched comparison group to evaluate the impact of UCMyRx on HbA1c and systolic blood pressure (SBP) among black patients with type 2 diabetes, relative to usual care. Participants: Individuals with type 2 diabetes identified as either black or African American in the EHR that were ≥ 18 years of age that had the following observations during the study window (03/02/2013–12/31/18: (1) HbA1C ≥ 8%, at least once, anywhere between 365 days before and 14 days after the UCMyRx visit and a follow-up HbA1c measure within 120 to 365 days after the visit and/or (2) SBP ≥ 140 mmHg at least once between 365 days before and 14 days after the UCMyRx visit that had a follow-up SBP measure within 120 to 450 days after the visit. Intervention: UCMyRx pharmacists review labs and vital signs, perform medication reconciliation, use a standardized survey to assess barriers to medication adherence, and develop tailored interventions to improve medication adherence. Main Measures: Change in HbA1c and change in SBP from before to after the first UCMyRx visit. Key Results: Having at least one visit with a UCMyRx clinical pharmacist was associated with a significant reduction in HbA1c (− 0.4%, p value =.01); however, there was no significant impact on SBP (−.051 mmHg, p value = 0.74). Conclusions: The UCMyRx intervention is a useful strategy for improving HbA1c control among blacks with type 2 diabetes. [ABSTRACT FROM AUTHOR]