1. Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly.
- Author
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Barbosa, Bruno Teixeira, da Cruz Santos, Amilton, Frazão, Murillo, Petrucci, Tulio Rocha, Cucato, Gabriel Grizzo, Sarmento, Adriana Oliveira, Freitas, Eduardo D. S., de Lima, Anna Myrna Jaguaribe, and Brasileiro-Santos, Maria do Socorro
- Abstract
Background: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.Methods: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h;
n = 15) and with OSA (OSA: AHI ≥ 15 events/h;n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independentt test and Pearson’s correlation were performed. The significance level employed wasp ≤ 0.05.Results: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2 ) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = −0.63,p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2 S) levels significantly correlated with VE/VCO2slope (r = 0.66,p = 0.01); in addition, No-OSA group presented a positive correlation between oxygen consumption and O2 S (r = 0.66,p = 0.01), unlike the OSA group.Conclusions: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2 . The association between O2 S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly. [ABSTRACT FROM AUTHOR]- Published
- 2018
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