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A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (7), was isolated from the entomogenous fungus Setosphaeria sp. The structure of the new compound was elucidated by analysis of the 1D and 2D spectroscopic data as well as MS. Compounds 2, 5, 6 showed moderate cytotoxicity against six human tumor cell lines MCF-7, MGC-803, H1975, Huh-7, A549, and HeLa with IC50 values ranging from 23.04 to 96.91 μg·mL–1. [ABSTRACT FROM AUTHOR]

This paper presents the numerical simulations of two Richtmyer-Meshkov (RM) instability experiments using the conservative front-tracking method developed in (Mao, D. Towards front-tracking based on conservation in two space dimensions II, tracking discontinuities in capturing fashion. J. Comput. Phys., 226, 1550-1588 (2007)). The numerical results are compared with those obtained in (Holmes, R. L., Grove, J. W., and Sharp, D. H. Numerical investigation of Richtmyer-Meshkov instability using front-tracking. J. Fluid Mech., 301, 51-64 (1995)). The present simulations are generally in good agreement with those obtained by Holmes et al., and also capture the nonlinear and compessive phenomenon, i.e., the self-interactions of the transmitted and reflected wave edges, which was pointed out by Holmes et al. as the cause of the deceleration of the interfaces. However, the perturbation amplitudes and the amplitude growth rates of the interfaces obtained with the present conservative front-tracking method are a bit larger than those obtained by Holmes et al. [ABSTRACT FROM AUTHOR]