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Lately novel strategies to enhance the sensing properties on iron oxide have been proposed to achieve high performance gas sensors for acetone detection. In this working report, the synthesis of iron-glycerate (Fe-Gly) using glycerol to combine with Fe3+ is first presented. Depending on the thermal treatment, this compound can evolve into γ-Fe2O3, α/γ-Fe2O3 and α-Fe2O3. α/γ-Fe2O3 shows better sensing performance as far as acetone detection is concerned. Using the dual phases of α/γ-Fe2O3 as a fundamental building block, their sensing properties were further improved using Ni doping and Ru nanoparticles functionalization. The high response and selectivity to acetone detection was ascribed to the synergistic effects of unique nanosheets, mixed phases, rich oxygen vacancies and excellent catalytic activity of Ru nanoparticles. [ABSTRACT FROM AUTHOR]

This study aimed to study the association between rs12976445 polymorphism and the incidence of IA re-bleeding. Genotype and allele frequency analysis was performed to study the association between rs12976445 polymorphism and the risk of IA re-bleeding. Western blot, ELISA and real-time RT-PCR were conducted to measure the relative expression of miR-125a, ET1 mRNA and ET1 protein. Computational analysis and luciferase assays were utilized to investigate the association between the expression of miR-125a and ET1 mRNA. No significant differences were observed between IA patients with or without symptoms of re-bleeding. Subsequent analyses indicated that the T allele was significantly associated with the reduced risk of IA re-bleeding. In patients carrying the CC genotype, miR-125a level was up-regulated while ET1 mRNA/protein levels were reduced compared with those in patients carrying the CT or TT genotype. And ET1 mRNA was identified as a virtual target gene of miR-125a with a potential miR-125a binding site located on its 3'UTR. Accordingly, the ET mRNA/protein levels could be suppressed by the transfection of miR-125a precursors, but the transfection of ET1 siRNA exhibited no effect on the expression of miR-125a. Therefore, an increased level of miR-125a can lead to the increased risk of IA re-bleeding. Since miR-125a level is higher in CC-genotyped patients, it can be concluded that the presence of T allele in the rs12976445 polymorphism is associated with a lower risk of IA re-bleeding, and miR-125a may be used as a novel diagnostic and therapeutic target for IA rupture. [ABSTRACT FROM AUTHOR]

The thermodynamics for Kerr-AdS black hole in four dimensions is revisited using the recently proposed restricted phase space formalism, which includes the central charge C of the dual CFT and the chemical potential μ , but excludes the pressure and the conjugate volume, as thermodynamic variables. The Euler relation holds automatically, and the first order homogeneity of the mass and the zeroth order homogeneity of the intensive variables are made explicit. Thermodynamic processes involving each pair of conjugate variables are studied in some detail, with emphasis on the scaling properties of the equations of states. It turns out that the thermodynamic behavior of the Kerr-AdS black hole is very similar to that of the RN-AdS black hole studied earlier. In particular, it is found that, there is a first order supercritical phase equilibrium in the T - S processes at fixed nonvanishing angular momentum, while at vanishing angular momentum or at fixed angular velocities, there is always a non-equilibrium transition from a small unstable black hole state to a large stable black hole state. Moreover, there is a Hawking–Page phase transition in the μ - C processes. Due to the complicatedness of the Kerr metric, the exact critical point and the Hawking–Page temperature are worked out explicitly only in the slow rotating limit, however the characteristic thermodynamic properties do not rely on the slow rotating approximation. [ABSTRACT FROM AUTHOR]

Staphylocoagulase (Coa) is a virulence factor of Staphylococcus aureus (S. aureus) that promotes blood coagulation by activating prothrombin to convert fibrinogen to fibrin. Coa plays a crucial role in disease pathogenesis and is a promising target for the treatment of S. aureus infections. Here, we identified that isoquercitrin, a natural flavonol compound, can markedly reduce the activity of Coa at concentrations that have no effect on bacterial growth. Mechanistic studies employing molecular dynamics simulation revealed that isoquercitrin binds to Coa by interacting with Asp-181 and Tyr-188, thereby affecting the binding of Coa to prothrombin. Importantly, in vivo studies showed that isoquercitrin treatment significantly reduced the bacterial burden, pathological damage, and inflammation of lung tissue and improved the percentage of survival of mice infected with S. aureus Newman strain. These data suggest that isoquercitrin is a promising inhibitor of Coa that can be used for the development of therapeutic drugs to combat S. aureus infections. Key Points • Staphylocoagulase plays a key role in the pathogenesis of S. aureus infection. • We identified that isoquercitrin is a direct inhibitor of staphylocoagulase. • Isoquercitrin treatment can significantly attenuate S. aureus virulence in vivo. [ABSTRACT FROM AUTHOR]