1. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome.
- Author
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Deniz, Rulin, Gurates, Bilgin, Aydin, Suleyman, Celik, Husnu, Sahin, İbrahim, Baykus, Yakup, Catak, Zekiye, Aksoy, Aziz, Citil, Cihan, and Gungor, Sami
- Abstract
Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS ( n = 30) and in age and body mass index (BMI)-matched controls ( n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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