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1. Antibody-dependent cellular cytotoxicity of the optimized anti-CD20 monoclonal antibody ublituximab on chronic lymphocytic leukemia cells with the 17p deletion.

Author

Le Garff-Tavernier, M, Herbi, L, de Romeuf, C, Nguyen-Khac, F, Davi, F, Grelier, A, Boudjoghra, M, Maloum, K, Choquet, S, Urbain, R, Vieillard, V, and Merle-Béral, H

Subjects
*CHRONIC lymphocytic leukemia treatment, *CHRONIC lymphocytic leukemia, *ANTIBODY-dependent cell cytotoxicity, *KILLER cells, *CELL physiology, *PATIENTS
Abstract

The article presents a study which aims to determine whether ublituximab could be considered an adapted treatment for the group of high-risk chronic lymphocytic leukemia (CLL) patients. It notes that antibody-dependent cellular cytotoxicity (ADCC) efficacy is more dependent on the intrinsic resistance of the CLL target cells than on the natural killer (NK) cell functionality. It concludes that ublituximab showed a promising overall response rate in CLL patients at a relatively low-dose regimen.

Published
2014
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