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Start Over Author "Hickman-Miller, Heather D." Publisher springer nature
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1. Youth has its privileges: maturation inhibits DC cross-priming.

Author

Hickman-Miller, Heather D and Yewdell, Jonathan W

Subjects
*CYTOLOGICAL research, *DENDRITIC cells, *T cells, *LYMPHOCYTES, *SUPPRESSOR cells, *ANTIGEN presenting cells
Abstract

The article shows that activated dendritic cells fail to cross-prime CD8+ T cell responses. Viruses that infect professional antigen-presenting cells may have contributed to the evolution of cross-priming. Cross-priming of CD8+ T cells involves three specialized features of dendritic cells. In vitro activation of dendritic cells results in inhibition of cross-priming.

Published
2006
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