1. An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza.
- Author
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Xing, Man, Hu, Gaowei, Wang, Xiang, Wang, Yihan, He, Furong, Dai, Weiqian, Wang, Xinyu, Niu, Yixin, Liu, Jiaojiao, Liu, Hui, Zhang, Xiaoyan, Xu, Jianqing, Cai, Qiliang, and Zhou, Dongming
- Subjects
SARS-CoV-2 ,COMBINED vaccines ,T cells ,BOOSTER vaccines ,INFLUENZA ,COVID-19 vaccines - Abstract
Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses continue to pose a severe global health burden. Thus, we developed a chimpanzee adenovirus-based combination vaccine, AdC68-HATRBD, with dual specificity against SARS-CoV-2 and influenza virus. When used as a standalone vaccine, intranasal immunization with AdC68-HATRBD induced comprehensive and potent immune responses consisting of immunoglobin (Ig) G, mucosal IgA, neutralizing antibodies, and memory T cells, which protected the mice from BA.5.2 and pandemic H1N1 infections. When used as a heterologous booster, AdC68-HATRBD markedly improved the protective immune response of the licensed SARS-CoV-2 or influenza vaccine. Therefore, whether administered intranasally as a standalone or booster vaccine, this combination vaccine is a valuable strategy to enhance the overall vaccine efficacy by inducing robust systemic and mucosal immune responses, thereby conferring dual lines of immunological defenses for these two viruses. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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