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Cedrol is a major bioactive compound present in the Cedrus atlantica with numerous biological properties. In this study, we elucidated the neuroprotective properties of cedrol against ischemic infarction in animal and in vitro studies. A cerebral ischemic/reperfusion model was induced in adult Wistar rats, and oxygen–glucose deprivation/reperfusion was induced in SH-SY5Y neuronal cells and treated with different concentrations of cedrol. The percentage of water content, cerebral infarct, and neurological deficit score was assessed in experimental rats. The acetylcholinesterase activity and inflammatory cytokines were quantified to analyze the anti-inflammatory potency of cedrol. Oxidative stress marker malondialdehyde and antioxidants were quantified to evaluate the antioxidant potency of cedrol in an ischemic condition. The neuroprotective potency of cedrol was confirmed by histopathological analysis of the brain tissue of cedrol-treated I/R-induced rats. In in vitro studies, the MTT and LDH assays were performed in cedrol-treated OGD/R SH-SY5Y cells to analyze the cytoprotective effect of cedrol. The anti-inflammatory property of cedrol was confirmed by quantifying the pro-inflammatory cytokine levels in OGD/R-induced cedrol-treated SH-SY5Y cells. The results obtained prove that cedrol significantly prevents brain edema, neurological deficits, acetylcholinesterase activity, and oxidative damage in ischemic-induced rats. It inhibited neuroinflammation in ischemic-induced rats and also in in vitro models. The neuroprotective effect of cedrol during an ischemic condition was authentically established with histological analysis in an animal model and cell survival assays in an in vitro model. Overall, our results confirm that cedrol is a potent alternative drug to treat cerebral ischemia in the future. [ABSTRACT FROM AUTHOR]

Mortise and tenon joint is a key connecting component in timber-framed architecture. Accurately assessing the damage to joints is crucial for the structural design of wooden buildings. This study conducted fatigue tests at three stress levels (70%, 100%, and 130%) based on the maximum stress from static bending tests to analyze the impact of different stress levels on the fatigue performance of mortise and tenon joints. The results showed that the deformation increased as the stress level increased. The energy loss per cycle de-creased and then increased at 130% stress level, and remained essentially constant at 70% and 100% levels. Then, micro-CT scanning was performed on the specimens after fatigue testing. The ambient occlusion algorithm was used to identify the outer boundaries of the tenon, which can distinguish internal cracks from outside air. The sphericity index was used to differentiate between pores and cracks. Three-dimensional visualization analysis was performed on the specimens, and the obtained information on pores and cracks was quantitatively analyzed. The results indicated that deformation and fracture of the tenon were the primary causes of joint damage. The layer-by-layer porosity of the undeformed portion of the tenon remained essentially constant and was lower than that of the fractured region and higher than that of the deformed region. This study analyzed the damage behavior of mortise and tenon joints under different stress levels, contributing to the design and protection of wooden structure buildings. [ABSTRACT FROM AUTHOR]

Background: Metabolic Syndrome (MetS) is a widely observed metabolic disorder that is increasingly prevalent worldwide, leading to substantial societal consequences. Previous studies have conducted two separate meta-analyses to investigate the relationship between MetS and air pollutants. However, these studies yielded conflicting results, necessitating a thorough systematic review and meta-analysis to reassess the link between different air pollutants and the risk of developing MetS. Methods: We conducted a comprehensive search of relevant literature in databases including PubMed, Embase, Cochrane Library, and Web of Science up to October 9, 2023. The search was specifically restricted to publications in the English language. Following the screening of studies investigating the correlation between air pollution and MetS, we utilized random-effects models to calculate pooled effect sizes along with their respective 95% confidence intervals (CIs). We would like to highlight that this study has been registered with PROSPERO, and it can be identified by the registration number CRD42023484421. Results: The study included twenty-four eligible studies. The results revealed that an increase of 10 μg/m3 in annual concentrations of PM1, PM2.5, PM10, NO2, SO2, and O3 was associated with a 29% increase in metabolic syndrome (MetS) risk for PM1 (OR = 1.29 [CI 1.07–1.54]), an 8% increase for PM2.5 (OR = 1.08 [CI 1.06–1.10]), a 17% increase for PM10 (OR = 1.17 [CI 1.08–1.27]), a 24% increase for NO2 (OR = 1.24 [CI 1.01–1.51]), a 19% increase for SO2 (OR = 1.19 [CI 1.04–1.36]), and a 10% increase for O3 (OR = 1.10 [CI 1.07–1.13]). Conclusion: The findings of this study demonstrate a significant association between exposure to fine particulate matter (PM1, PM2.5, PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and the incidence of metabolic syndrome (MetS). Moreover, the results suggest that air pollution exposure could potentially contribute to the development of MetS in humans. [ABSTRACT FROM AUTHOR]

We examined the association between social vulnerability and HIV diagnoses, linkage to HIV medical care, and viral suppression among adults in the Southern U.S. Data from CDC's National HIV Surveillance System (NHSS) were used to determine census tract-level HIV diagnosis rates and percentages of persons linked to care within one month and with viral suppression within six months of diagnosis among Black/African American, Hispanic/Latino, and White adults aged ≥ 18 years residing in the Southern U.S. in 2018. Census tract-level social vulnerability data were obtained from the 2018 CDC Social Vulnerability Index (SVI). Rate and proportion ratios were used to determine the difference between the lowest quartile of SVI scores (Q1) and the highest quartile (Q4) by age group, transmission category, and region of residence and stratified by sex assigned at birth. Areas with the highest social vulnerability (Q4) had the highest rates of HIV diagnoses (Black: 56.5, Hispanic/Latino: 27.2, and White: 10.3). Those in Q4 also had the lowest percentages of adults linked to care (Black: 76.1%, Hispanic/Latino: 81.2%, and White: 77.8%), and the lowest percentages of adults with viral suppression (Black: 59.8%, Hispanic/Latino: 68.4%, and White: 65.7%). This ecological study found an association between social vulnerability, HIV diagnoses, and poorer care outcomes among Black/African American, Hispanic/Latino, and White adults. Tailoring interventions and improving access for persons residing in areas with the highest social vulnerability is necessary to reduce HIV transmission and improve health outcomes in the Southern U.S. [ABSTRACT FROM AUTHOR]

Electrochemical methods have been widely applied in the treatment of phenol wastewater for the past few years. However, conventional electrochemical advanced oxidation processes (EAOPs) generally encounter the problem of electrode passivation and the energy consumption required for mineralization is high. In this work, we reported the treatment of phenol wastewater by electrochemical bromination method in a flow electrolysis cell. The Ti/Sb-SnO2/PbO2 electrode was prepared and used as anode. The experiments were carried out under different initial pH, KBr concentrations, current densities, and volumetric flow rates. The generated 2,4,6-tribromophenol (TBP) could be easily separated from the electrode surface and electrolyte. The brominated intermediates were identified by GC/MS. The removal efficiencies for phenol and COD were 100% and 82.7%, respectively, under the best operational conditions (current density of 40 mA cm−2, KBr concentration of 0.074 mol L−1, initial pH of 1.0, and volumetric flow rate of 114 mL min−1). Furthermore, our electrochemical bromination method offered a high apparent current efficiency (ACE) of 276.6% and a low energy consumption (EC) of 4.54 × 10−3 kWh gCOD−1 after 40 min of electrolysis time, indicating that this process was suitable for phenol wastewater treatment. [ABSTRACT FROM AUTHOR]

4-pyridinemethanol is well known as an important pharmaceutical intermediate and chemical raw material. Its preparation by electrochemical method has seen a recent explosion of interest. In this paper, we report the synthesis of 4-pyridinemethanol by electrochemical reduction of ethyl isonicotinate using an undivided flow electrolysis cell. The experiments were conducted under different conditions, including applied charge, initial concentration of ethyl isonicotinate and H2SO4, current density, and electrode materials. The yield of 4-pyridinemethanol reached up to 71 % under the optimal conditions. The oxidation of target product was avoided by using Ti/IrO2 anode in the absence of membrane separation. Furthermore, the repeat cycle experiments and cyclic voltammetric experiments showed that this approach possessed good reproducibility and stability. [ABSTRACT FROM AUTHOR]

Sulfadiazine (SDZ) was a persistent sulfonamide antibiotic with a potential risk to human health. The waste dipping syrup was considered useless and environmentally unfriendly solution. In this work, carbonyl-, hydroxyl-, and amino-functionalized microporous carbonaceous nanospheres were synthesized using waste dipping syrup with glucose, fructose, and nitrogen, which was used as precursor for hydrothermal and pyrolysis process. The products were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transformed infrared spectroscopy (FTIR), the point of zero charge (PZC), Xray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET). The carbonaceous nanospheres with large BET surface area (924.528 m2/g), micropores (2.127 nm), and high micro-porosity (89.54 %) allowed the rapid diffusion of SDZ (0.512nm×0.738 nm) into micropores of nanospheres. The majority SDZ (initial concentration = 20 mg/L) was removed (>96.8%) in the presence of 1.0 g/L nanoparticles after 40-min reaction at pH = 6.0. The adsorption capacity of SDZ onto nanospheres was 96.6 mg/g. The adsorption kinetic and equilibrium followed pseudo-first-order model and Langmuir isotherm, respectively. The intra-particle diffusion model indicated a three-step adsorption process. In addition, the regenerated nanospheres could be reused over four recycles. The optimal fabrication was realized at lower hydrothermal and pyrolysis temperature of 180 °C and 400 °C, respectively, which involved no additional chemical activating agent and had a high yield (70.8 %). Collectively, hydroxylation, carboxylation, amination, large specific surface area, and multi-microporosity may be responsible for improved adsorption performance of SDZ onto nanospheres. The findings provided a novel pathway for SDZ-loading wastewater treatment using waste syrup. [ABSTRACT FROM AUTHOR]

Arsenic (As) and cadmium (Cd) co-contamination has been a typical problem in Chinese agricultural land adjacent to historical metal mining and smelting activities. Remediation of As and Cd in soil has encountered many difficulties owing to the distinct nature of the two metal(loid)s. In this study, we developed a remediation scheme by adding a hexadecyltrimethylammonium (HDTMA)-modified zeolite to a mining site soil and evaluated the immobilization effect. The result of the increased surface zeta potential indicates that the HDTMA modification conferred the zeolite with adsorbability towards As through the cationic surfactant head. The addition of the highest dosage of HDTMA-modified zeolite (10%) to the contaminated soil greatly improved soil organic matter by 1.4 times, partly due to the elevated C loading on the zeolite from HDTMA. Sequential extraction results show that the addition of HDTMA-modified zeolite not only increased the residual fraction of As (by 2.7–5.9%) but also reduced the toxicity-related fraction (by 2.3–2.7%) when compared to the unmodified zeolite and blank treatments. The oxidizable fractions of Cd in the modified zeolite treatment were significantly higher than that in the blank soil. Besides, the exchangeable fractions of Cd were all significantly reduced in the zeolite treatments. Enzyme activity assays show that the HDTMA-modified zeolite treatment could greatly improve soil microbial environment. The physiologically based extraction test (PBET) also proved that the bioavailability of As and Cd was reduced after the modified zeolite treatment. [ABSTRACT FROM AUTHOR]

The bi-functional Ni–W@C catalysts were prepared by one-pot reduction–carbonization method and used in hydrogenolysis of cellulose as well as raw lignocellulosic biomass to chemicals. The catalytic performance for cellulose conversion showed that it was more favorable for ethylene glycol (EG) production, obtaining the highest EG yield 60.1% over the Ni–W@C700 catalyst. The Ni–W@C bimetallic catalysts are systematically characterized with BET, XRD, Raman, XPS, TEM techniques and experiments to probe the active catalytic sites of the catalysts. The effects of calcination temperature of Ni–W catalysts, reaction time, temperature and H2 pressure on cellulose hydrogenolysis were investigated in detail. The Ni particles could lead to produce more W5+ active sites, which promotes the glucose retro-aldol condensation to break the target C–C bonds. Metallic Ni catalyzed C=O hydrogenation and C–C hydrogenolysis, which could also avoid the coke formation. The EG selectivity was dependent on the synergy of WOx and Ni metal sites. In addition, this synergistic effect between the metal and WOx could promote lignin component degradation in direct conversion of untreated raw lignocellulosic biomass, obtaining the propyl monophenolics including guaiacylpropane, syringylpropane and p-n-propylphenol with a total yield of 17.3 wt% besides EG. [ABSTRACT FROM AUTHOR]

Main conclusion: Eight variants in ZmHKT1 promoter were significantly associated with root diameter, four haplotypes based on these significant variants were found, and Hap2 has the largest root diameter.Roots play an important role in uptake of water, nutrients and plant anchorage. Identification of gene and corresponding SNPs associated with root traits would enable develop maize lines with better root traits that might help to improve capacity for absorbing nutrients and water acquisition. The genomic sequences of a salt tolerance gene ZmHKT1 was resequenced in 349 maize inbred lines, and the association between nucleotide polymorphisms and seedling root traits was detected. A total of 269 variants in ZmHKT1 were identified, including 226 single nucleotide polymorphisms and 43 insertions and deletions. The gene displayed high level of nucleotide diversity, especially in non-genic regions. A total of 19 variations in untranslated region of ZmHKT1 were found to be associated with six seedling traits. Eight variants in promoter region were significantly associated with average root diameter (ARD), four haplotypes were found based on these significant variants, and Hap2 has the largest ARD. Two SNPs in high-linkage disequilibrium (SNP-415 and SNP 2169) with pleiotropic effects were significantly associated with plant height, root surface area, root volume, and shoot dry weight. This result revealed that ZmHKT1 was an important contributor to the phenotypic variations of seedling root traits in maize, these significant variants could use to develop functional markers to improve root traits. [ABSTRACT FROM AUTHOR]

We report a passively Q-switched all-fiber Yb-doped laser using the structure of step-index multimode fiber and graded-index fiber (SIMF-GIMF) as a new saturable absorber (SA) based on the nonlinear multimode interference (NL-MMI). Through bending the SA to a certain state, we obtain a stable Q-switched laser operation with the shortest pulse duration of 4.37 μs and a corresponding repetition rate of 147.6 kHz with center at 1,039 nm. The maximum average output power and single pulse energy are recorded to be 2.409 mW and 16.3 nJ, respectively. To the best of our knowledge, this paper confirms experimentally for the first time Q-switched laser operation based on SIMF-GIMF SA in all-fiber lasers. In addition, we also observed unstable Q-switched mode-locking operation. All-fiber lasers based on SIMF-GIMF SA are attractive for practical applications and undergo no damage and performance degradation with time. [ABSTRACT FROM AUTHOR]

Coatings are required on mold copper plates to prolong their service life through enhanced hardness, wear resistance, and oxidation resistance. In the present study, NiCr-30 wt.%CrC ceramic-metallic (cermet) layers were deposited by high velocity oxy-fuel (HVOF) spraying on different designed bond layers, including electroplated Ni, HVOF-sprayed NiCr, and double-decker Ni-NiCr. Annealing was also conducted on the gradient coating (GC) with NiCr bond layer to improve the wear resistance and adhesion strength. Coating microstructure was investigated by scanning electron microscopy and x-ray diffraction analysis. Mechanical properties including microhardness, wear resistance, and adhesion strength of the different coatings were evaluated systematically. The results show that the types of metallic bond layer and annealing process had a significant impact on the mechanical properties of the GCs. The GCs with electroplated Ni bond layer exhibited the highest adhesion strength (about 70 MPa). However, the GC with HVOF-sprayed NiCr bond layer exhibited better wear resistance. The wear resistance and adhesion strength of the coating with NiCr metallic bond layer were enhanced after annealing. [ABSTRACT FROM AUTHOR]

As a temporarily protective reaction for active hydrogen group, acetylation is reversible and responsive to low pH value. According to the reaction, pH-sensitive β-cyclodextrin (β-CD) was synthesized in the first step of our research. During the synthesis, the acetal groups including linear acetal (LA) groups and cyclic acetal (CA) groups were successfully modified onto β-CD. Particularly, the structural details of acetalated β-CD (Ac-β-CD) were greatly influenced by reaction time. Furthermore, in respect to water solubility, Ac-β-CDs exhibited different pH response properties due to their different structure. In the second step, Ac-β-CD1 nanoparticles were prepared by a single oil-in-water (O/W) emulsion technique using a biocompatible emulsifier, gelatin. Meanwhile, gelatin was absorbed onto the surface of nanoparticle, which was confirmed by FTIR spectra. The formed nanoparticles showed monodispersion and nearly spherical morphology. In order to obtain optimal preparing conditions, the effects of preparative parameters such as gelatin concentration, Ac-β-CD concentration, and water/oil ratio on properties including diameters and zeta potential as well as gelatin content were investigated. Moreover, the pH response properties of nanoparticle were characterized by transparency of nanoparticle solution. Finally, in vitro cell culture confirmed that Ac-β-CD nanoparticle could support cell survival and enhance cell viability. [ABSTRACT FROM AUTHOR]

FeO/carbon nanotubes (FeO/CNTs) nanocomposites were prepared by polylol high-temperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol. After surface modification with hexanediamine, folate was covalently linked to the amine group of magnetic FeO/CNTs nanocomposites. The products were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometry. Then FeO/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel. The results indicated that the FeO/CNTs had a favorable release property for epirubicin and paclitaxel, and thus had potential application in tumor-targeted combination chemotherapy. [ABSTRACT FROM AUTHOR]

Background: The first prospective trial for resective surgery combined with corpus callosotomy (CCT) was performed to investigate the outcomes of the combined surgery in children with Lennox-Gastaut syndrome (LGS) without focal lesion on brain MRI. Methods: This study enrolled 68 children with LGS and without focal lesion on brain MRI, of which 25 received medicine (medicine group) and 43 underwent surgery (surgery group), including 20 with exclusively resective surgery (exclusively resection subgroup) and 23 with resective surgery combined with CCT (combined CCT subgroup). All patients were followed for 3-5 years. Results: Significant differences in seizure control were observed between the medicine group and the exclusively resection subgroup and combined CCT subgroup at the 1-year, 3-year, and 5-year follow-ups. There was a trend that the children with resection combined with CCT had better seizure control than those with exclusively resection at the three follow-ups, but this could not be verified by the statistical method used. Furthermore, significant differences were not observed in seizure control between children with different MRI findings, age at surgery, or pathology in the surgery group. The percentage of long-term seizure-free did not remain as high as the percentage of early stage seizure-free at 1-year follow-up. However, the children with combined CCT surgery demonstrated more postoperative improvement than the children with resective surgery alone based on the mean QOL score (10.78 vs. 5.75, p = 0.0152) and full-scale IQ (7.91 vs. 4.55, p = 0.0446). Conclusions: Resective surgery combined with CCT can provide favorable seizure control and obvious improvements in QOL and IQ in children with LGS. This combined approach can be performed in carefully selected LGS children without focal lesions and can localize the epileptogenic zone following a comprehensive preoperative evaluation. [ABSTRACT FROM AUTHOR]

Lactate-utilizing bacteria play important roles in the production of Chinese strong-flavored liquor (CSFL). However, the identity of these bacteria and their lactate-utilizing properties are largely unknown. Here, a lactate-utilizing, butyrate-producing bacterium BPY5 was isolated from an old fermentation pit for CSFL production. The isolate represented a novel species belonging to Clostridium cluster XIVa of family Lachnospiraceae based on phylogenetic analysis using 16S rRNA gene sequences. Strain BPY5 could ferment lactate into butyrate as the major metabolic product. Butyrate was significantly formed at initial lactate concentration from 66 to 104 mM, but substantially declined when initial lactate exceeded 133 mM. At initial lactate concentration of 66 mM, lactate conversion was independent on initial pH from 5.5 to 7.0, but the conversion was completely inhibited when pH dropped below 4.8. Nevertheless, the inhibition on lactate conversion was largely relieved by the addition of acetate, suggesting that exogenous acetate could enhance lactate conversion at low pH condition. Additionally, lactate in CSFL-brewing wastewater was dramatically removed when inoculated with strain BPY5. These results implicate that the isolate may be applied for the industrial production of butyrate or the recovery of butyrate from lactate-containing wastewater. [ABSTRACT FROM AUTHOR]

A group of nine states in the Southern United States, hereafter referred to as the targeted states, has experienced particularly high HIV diagnosis and case fatality rates. To provide additional information about the HIV burden in this region, we used CDC HIV surveillance data to examine characteristics of individuals diagnosed with HIV in the targeted states (2011), 5-year HIV and AIDS survival, and deaths among persons living with HIV (2010). We used multivariable analyses to explore the influence of residing in the targeted states at diagnosis on deaths among persons living with HIV after adjustment for demographics and transmission risk. In 2011, the targeted states had a higher HIV diagnosis rate (24.5/100,000 population) than the US overall (18.0/100,000) and higher proportions than other regions of individuals diagnosed with HIV who were black, female, younger, and living in suburban and rural areas. Furthermore, the targeted states had lower HIV and AIDS survival proportions (0.85, 0.73, respectively) than the US overall (0.86, 0.77, respectively) and the highest death rate among persons living with HIV of any US region. Regional differences in demographics and transmission risk did not explain the higher death rate among persons living with HIV in the targeted states indicating that other factors contribute to this disparity. Differences in characteristics and outcomes of individuals with HIV in the targeted states are critical to consider when creating strategies to address HIV in the region, as are other factors identified in previous research to be prominent in the region including poverty and stigma. [ABSTRACT FROM AUTHOR]

Biodegradable hydrogels carrying adipose-derived stem cells (ASCs) have been highlighted with promising potential regarding adipose tissue engineering. In this study, covalently crosslinked natural/synthetic hybrid hydrogels were prepared from methacrylated water soluble chitosan ( N-succinyl-chitosan, SCS) and poly(ethylene glycol) (PEG) by photoinitiaing polymerization under the existence of Irgacure 2959 and the irradiation of UV light. The effect of the incorporated PEG on the in vitro morphologies, equilibrium swelling, weight loss and compressive modulus of SCS/PEG hybrid hydrogels in phosphate buffered saline (PBS) at 37 °C were studied. In order to evaluate the ability of hydrogels to effectively deliver the adipogenic factor, insulin was entrapped within hydrogels by copolymerizing methacrylated SCS/PEG. The insulin would be released from the hydrogels into the local microenvironment via the controlled weight ratio of SCS/PEG. Results demonstrated that the hybrid hydrogel with 10 wt% PEG showed a higher efficiency of insulin delivery compared to the control hydrogels. ASCs were seeded into the insulin-loaded SCS/PEG hydrogels in vitro to assess the biological performance and applicability of hydrogels as cell carriers. These characteristics provide potential opportunities for the hybrid SCS/PEG hydrogels as injectable scaffolds in soft tissue engineering applications. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

We theoretically study the formation of multiple dark photovoltaic soliton splitting in the quasi-steady-state and steady-state regimes under open-circuit conditions. We find that the initial width of the dark notch at the entrance face of the crystal is a key parameter for generating an even (or odd) number sequence of dark coherent photovoltaic solitons. If the initial width of the dark notch is small, only a fundamental soliton or Y-junction soliton pair is generated. As the initial width of the dark notch is increased, the dark notch tends to split into an odd (or even) number of multiple dark photovoltaic solitons, which realizes a progressive transition from a low-order soliton to a sequence of higher-order solitons. The soliton pairs far away from the centre have bigger width and less visibility. In addition, when the distance from the centre of the dark notch increases, the separations between adjacent dark stripes become slightly smaller. [ABSTRACT FROM AUTHOR]

Direct electrochemical reduction of mixed TiO2 and NiO powders to TiNi alloy has been successfully demonstrated in molten CaCI2 at 900°C by constant voltage electrolysis. The electrolysis energy consumption was as low as 23.4 kWh/kg-TiNi, although the current efficiency was 20.5% in the preliminary experiments. During the process, NiO was first reduced to Ni at high speed, accompanied by TiO2 being perovskitized to CaTiO3-x which was gradually reduced to Ni3Ti and TiNi, assisted by the depolarization of the preformed Ni. The cell voltage for preparation of the TiNi alloy was lower than that for Ti. Adjusting the cell voltage not only affected the reduction speed, but also offered a convenient access to the preparation of the nickel/perovskite composite. [ABSTRACT FROM AUTHOR]

Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C–N bond with high atom economy. The research progress in metals catalyzed hydroamination of alkenes and alkynes from the perspective of reaction mechanism is categorized and summarized. [ABSTRACT FROM AUTHOR]

Osteogenic differentiation and commitment of mesenchymal stem cells (MSCs) is a complex process that is induced and regulated by various biological factors and biophysical cues. Although cell spreading area, as a biophysical cue, has been demonstrated to play a critical role in the regulation of osteogenic differentiation of MSCs, it is unclear how it affects the maintenance of the committed phenotype after osteogenic differentiation of MSCs. In this study, poly (vinyl alcohol) was micropatterned on a tissue culture polystyrene surface, and the micropatterns were used to culture MSCs to control their cell spreading area. The influence of cell spreading area on osteogenic differentiation and maintenance of the differentiated phenotype of MSCs was investigated. MSCs with a larger spreading area showed a higher degree of osteogenic differentiation, slower loss of differentiated phenotype and slower re-expression of stem cell markers compared with MSCs with a smaller spreading area. A large cell spreading area was beneficial for osteogenic differentiation of MSCs and maintenance of their differentiated phenotype. [ABSTRACT FROM AUTHOR]

We demonstrate an all-fiber mode locked laser based on hybrid structure of multimode fiber saturable absorber (SA) that can realize both conventional soliton and stretched-pulse states. Stable 16.44 MHz conventional soliton pulses are achieved by injecting 80 mW threshold pump power. By increasing the incident pump power to 420 mW, the laser evolves from soliton operation into stretched-pulse mode locking state. 310 fs stretched-pulse are obtained with the same repetition rate as the soliton pulses. The center wavelength and its 3 dB spectrum bandwidth are 1603 nm and 14.2 nm, respectively. For the first time, we experimentally confirm transition between conventional soliton and stretched-pulse in 1.5 μm mode-locked fiber laser by introducing multimode optical fiber SA. Moreover, the maximum single pulse energy of nearly 1 nJ is achieved. Such all-fiber mode-locked lasers based on hybrid structure of multimode fiber are attractive for practical applications without damage and the limitation of life time. [ABSTRACT FROM AUTHOR]