The regional hydrology and ecosystems of the northeastern margin of the Qinghai–Tibetan Plateau have changed over the past 40 years driven by intense human activity and regional climate changes. Annual mean air temperature has increased in the region. Streamflow from the northeastern margin of the Qinghai–Tibetan Plateau has decreased significantly. Overall, a number of Alpine step meadows and Alpine frigid meadows have seriously degraded. Degeneration of vegetation and grassland led to desertification and frequently induced dust storms. With the continuous increase in cultivated land area, grassland area in the region has dropped significantly since the 1960s. At present, degraded grassland occupies about 83% of total usable grassland area. As the number of livestock increased, range condition deteriorated and the carrying capacity was reduced. The forest area in the northeastern margin of the Qinghai–Tibetan Plateau has decreased by 20%, and the local ecosystem has become very fragile. Given the relatively stable weather conditions, the northeastern margin of the Qinghai–Tibetan Plateau can be characterized by its three major ecosystems: grassland ecosystem, forest ecosystem and wetland ecosystem, which are crucial in maintaining the ecological stability. Changes in these ecosystems could influence sustainable development in the region. To avoid further deterioration of the environment and ecosystems, it is important to establish and implement ecosystem protection planning. Some effective measures are essential in this respect, including technical and political considerations. [ABSTRACT FROM AUTHOR]