1. Bioconversion of compactin into pravastatin by Streptomyces sp.
- Author
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Joo-Woong Park, Joo-Kyung Lee, Tae-Jong Kwon, Dong-Hee Yi, Young-Jun Kim, Seong-Hoon Moon, Hyun-Hyo Suh, Sang-Mo Kang, and Yong-Il Park
- Subjects
STREPTOMYCES ,STREPTOMYCETACEAE ,HYPERCHOLESTEREMIA ,HYPERLIPIDEMIA ,THERAPEUTICS ,CLINICAL medicine - Abstract
Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l
-1 from 750 mg compactin l-1 in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l-1 and 1000 mg pravastatin l-1 , respectively, with the conversion rate of 10 mg l-1 h-1 . Continuous feeding of compactin increased production of pravastatin to 15 mg l-1 h-1 . [ABSTRACT FROM AUTHOR]- Published
- 2003
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