1. Autoantibodies vex the vasculature.
- Author
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Kallenberg, Cees GM, Stegeman, Coen A, and Heeringa, Peter
- Subjects
- *
VASCULITIS , *GRAM-negative bacteria , *GRAM-negative bacterial diseases , *ESCHERICHIA coli , *IMMUNOGLOBULINS - Abstract
The article reports on results of a study of the mechanism behind pauci-immune small-vessel vasculitides. The study showed that infection with a Gram-negative bacterium such as Escherichia coli may trigger disease in susceptible individuals by inducing the production of antibodies to a human protein expressed on neutrophils, lysosomal membrane protein-2.
- Published
- 2008
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